The research objective of this contract is to design and construct a transgenic rat that either lacks or overexpresses a specific gene that may be involved in the cellular injury or repair of brain cells within the central nervous system (CNS) following cerebral ischemia.
Chan, P H; Kawase, M; Murakami, K et al. (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18:8292-9 |
Murakami, K; Kondo, T; Kawase, M et al. (1998) Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 18:205-13 |