Abstract

The purpose of this contract is to develop improved methodologies to assess diabetic neuropathy, with particular emphasis upon peripheral autonomic function. Specific objectives are: 1.1 Development of methods to quantitate postganglionic sympathetic sudomotor denervation in diabetic neuropathy. 1.2 Evaluation of the use of the venoarteriolar reflex in defining postganglionic sympathetic vasomotor denervation of human skin in diabetic neuropathy. 1.3. Evaluation of a miniaturized laser doppler probe to define the proximodistal distribution of denervation of the muscle resistance bed. 1.4 Development of methods to define the distribution of postganglionic vasomotor denervation and dysfunction in diabetic neuropathy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS072302-001
Application #
3670859
Study Section
Project Start
1987-09-30
Project End
1990-09-29
Budget Start
1988-03-31
Budget End
1989-09-29
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Arnold, R W; Gould, A B; MacKenzie, R et al. (1994) Lack of global vagal propensity in patients with oculocardiac reflex. Ophthalmology 101:1347-52
Low, P A; Opfer-Gehrking, T L; Kihara, M (1992) In vivo studies on receptor pharmacology of the human eccrine sweat gland. Clin Auton Res 2:29-34
Low, P A; Opfer-Gehrking, T L (1992) Differential effects of amitriptyline on sudomotor, cardiovagal, and adrenergic function in human subjects. Muscle Nerve 15:1340-4
Low, P A; Nickander, K K (1991) Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes 40:873-7
Zollman, P J; Awad, O; Schmelzer, J D et al. (1991) Effect of ischemia and reperfusion in vivo on energy metabolism of rat sciatic-tibial and caudal nerves. Exp Neurol 114:315-20
Kihara, M; Nickander, K K; Low, P A (1991) The effect of aging on endoneurial blood flow, hyperemic response and oxygen-free radicals in rat sciatic nerve. Brain Res 562:1-5
Sandroni, P; Benarroch, E E; Low, P A (1991) Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure. J Appl Physiol 71:1563-7
Cameron, N E; Cotter, M A; Low, P A (1991) Nerve blood flow in early experimental diabetes in rats: relation to conduction deficits. Am J Physiol 261:E1-8
Torres, N E; Zollman, P J; Low, P A (1991) Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography. Brain Res 550:129-32
Kihara, M; Low, P A (1990) Regulation of rat nerve blood flow: role of epineurial alpha-receptors. J Physiol 422:145-52

Showing the most recent 10 out of 13 publications