Abstract

The research objective of this contract is for the completion of empirical testing, under experimental conditions, of the transgenic rat model that overexpresses SOD-1 to assess its involvement in the cellular injury or repair of brain cells within the central nervous system (CNS) following cerebral ischemia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS082386-005
Application #
6288449
Study Section
Project Start
1998-01-01
Project End
2000-12-31
Budget Start
2000-03-21
Budget End
2000-12-31
Support Year
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Sugawara, Taku; Chan, Pak H (2003) Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 5:597-607
Noshita, Nobuo; Sugawara, Taku; Lewen, Anders et al. (2003) Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke 34:1513-8
Kim, Gyung W; Kondo, Takeo; Noshita, Nobuo et al. (2002) Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 33:809-15
Sugawara, Taku; Noshita, Nobuo; Lewen, Anders et al. (2002) Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 22:209-17
Kim, Gyung W; Chan, Pak H (2002) Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab 22:798-809
Sugawara, Taku; Lewen, Anders; Noshita, Nobuo et al. (2002) Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98
Sugawara, T; Noshita, N; Lewen, A et al. (2001) Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia. Stroke 32:2388-93
Morita-Fujimura, Y; Fujimura, M; Yoshimoto, T et al. (2001) Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke 32:2356-61
Chan, P H; Kawase, M; Murakami, K et al. (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18:8292-9