The research objective of this contract is for the completion of empirical testing, under experimental conditions, of the transgenic rat model that overexpresses SOD-1 to assess its involvement in the cellular injury or repair of brain cells within the central nervous system (CNS) following cerebral ischemia.

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Stanford University
Schools of Medicine
United States
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Sugawara, Taku; Chan, Pak H (2003) Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 5:597-607
Noshita, Nobuo; Sugawara, Taku; Lewen, Anders et al. (2003) Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke 34:1513-8
Kim, Gyung W; Kondo, Takeo; Noshita, Nobuo et al. (2002) Manganese superoxide dismutase deficiency exacerbates cerebral infarction after focal cerebral ischemia/reperfusion in mice: implications for the production and role of superoxide radicals. Stroke 33:809-15
Sugawara, Taku; Noshita, Nobuo; Lewen, Anders et al. (2002) Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci 22:209-17
Kim, Gyung W; Chan, Pak H (2002) Involvement of superoxide in excitotoxicity and DNA fragmentation in striatal vulnerability in mice after treatment with the mitochondrial toxin, 3-nitropropionic acid. J Cereb Blood Flow Metab 22:798-809
Sugawara, Taku; Lewen, Anders; Noshita, Nobuo et al. (2002) Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98
Morita-Fujimura, Y; Fujimura, M; Yoshimoto, T et al. (2001) Superoxide during reperfusion contributes to caspase-8 expression and apoptosis after transient focal stroke. Stroke 32:2356-61
Sugawara, T; Noshita, N; Lewen, A et al. (2001) Neuronal expression of the DNA repair protein Ku 70 after ischemic preconditioning corresponds to tolerance to global cerebral ischemia. Stroke 32:2388-93
Chan, P H; Kawase, M; Murakami, K et al. (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J Neurosci 18:8292-9