This is a multi-center study of normal structural and metabolic brain development in infants and children, being sponsored by NINDS, NIMH and NICHD. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) will be used to characterize brain development in relationship to behavior and cognition from ages 0 through 18 years, supplemented by diffusion tensor imaging (DTI) for ages 0 through 4 years. The project is planned for six years and involves a longitudinal design, repeated behavioral testing, and rescanning of subjects. This project will result in a representative, reliable and adequate database with which to characterize normal brain development, construct growth curves with which to evaluate individual brains, provide potential control data for studies of patients, and create developmentally-sensitive image analysis tools. A data sharing plan will be implemented to make this resource available to the medical and research community.
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| Lyle, Keith B; Dombroski, Brynn A; Faul, Leonard et al. (2017) Bimanual coordination positively predicts episodic memory: A combined behavioral and MRI investigation. Brain Cogn 118:71-79 |
| Nguyen, Tuong-Vi; Lew, Jimin; Albaugh, Matthew D et al. (2017) Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function. Psychoneuroendocrinology 76:206-217 |
| Nguyen, Tuong-Vi; Gower, Patricia; Albaugh, Matthew D et al. (2016) The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks. Psychoneuroendocrinology 70:122-33 |
| Ekert, Kaspar; Groeschel, Samuel; Sánchez-Albisua, Iciar et al. (2016) Brain morphometry in Pontocerebellar Hypoplasia type 2. Orphanet J Rare Dis 11:100 |
| Nguyen, Tuong-Vi; McCracken, James T; Albaugh, Matthew D et al. (2016) A testosterone-related structural brain phenotype predicts aggressive behavior from childhood to adulthood. Psychoneuroendocrinology 63:109-18 |
| Ducharme, Simon; Albaugh, Matthew D; Nguyen, Tuong-Vi et al. (2016) Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures. Neuroimage 125:267-279 |
| Walker, Lindsay; Chang, Lin-Ching; Nayak, Amritha et al. (2016) The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI). Neuroimage 124:1125-30 |
| Hair, Nicole L; Hanson, Jamie L; Wolfe, Barbara L et al. (2015) Association of Child Poverty, Brain Development, and Academic Achievement. JAMA Pediatr 169:822-9 |
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