Abstract

This is a multi-center study of normal structural and metabolic brain development in infants and children, being sponsored by NINDS, NIMH and NICHD. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) will be used to characterize brain development in relationship to behavior and cognition from ages 0 through 18 years, supplemented by diffusion tensor imaging (DTI) for ages 0 through 4 years. The project is planned for six years and involves a longitudinal design, repeated behavioral testing, and rescanning of subjects. This project will result in a representative, reliable and adequate database with which to characterize normal brain development, construct growth curves with which to evaluate individual brains, provide potential control data for studies of patients, and create developmentally-sensitive image analysis tools. A data sharing plan will be implemented to make this resource available to the medical and research community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS092320-002
Application #
6358421
Study Section
Project Start
1999-09-30
Project End
2005-09-29
Budget Start
2000-09-26
Budget End
2000-11-30
Support Year
Fiscal Year
2000
Total Cost
$59,215
Indirect Cost

  Institution

Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Farooqi, Nasr A I; Scotti, Martina; Lew, Ji Min et al. (2018) Role of DHEA and cortisol in prefrontal-amygdalar development and working memory. Psychoneuroendocrinology 98:86-94
Hamner, Taralee; Udhnani, Manisha D; Osipowicz, Karol Z et al. (2018) Pediatric Brain Development in Down Syndrome: A Field in Its Infancy. J Int Neuropsychol Soc 24:966-976
Lyle, Keith B; Dombroski, Brynn A; Faul, Leonard et al. (2017) Bimanual coordination positively predicts episodic memory: A combined behavioral and MRI investigation. Brain Cogn 118:71-79
Nguyen, Tuong-Vi; Wu, Mia; Lew, Jimin et al. (2017) Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development. Psychoneuroendocrinology 86:110-121
Nguyen, Tuong-Vi; Lew, Jimin; Albaugh, Matthew D et al. (2017) Sex-specific associations of testosterone with prefrontal-hippocampal development and executive function. Psychoneuroendocrinology 76:206-217
Nguyen, Tuong-Vi; Gower, Patricia; Albaugh, Matthew D et al. (2016) The developmental relationship between DHEA and visual attention is mediated by structural plasticity of cortico-amygdalar networks. Psychoneuroendocrinology 70:122-33
Ekert, Kaspar; Groeschel, Samuel; Sánchez-Albisua, Iciar et al. (2016) Brain morphometry in Pontocerebellar Hypoplasia type 2. Orphanet J Rare Dis 11:100
Nguyen, Tuong-Vi; McCracken, James T; Albaugh, Matthew D et al. (2016) A testosterone-related structural brain phenotype predicts aggressive behavior from childhood to adulthood. Psychoneuroendocrinology 63:109-18
Ducharme, Simon; Albaugh, Matthew D; Nguyen, Tuong-Vi et al. (2016) Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures. Neuroimage 125:267-279
Walker, Lindsay; Chang, Lin-Ching; Nayak, Amritha et al. (2016) The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI). Neuroimage 124:1125-30

Showing the most recent 10 out of 74 publications