The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

Project Start
1993-04-15
Project End
2005-09-14
Budget Start
1999-03-23
Budget End
2002-03-22
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Li, Rongling; O'Sullivan, Mary J; Robinson, Jennifer et al. (2009) Family history of myocardial infarction predicts incident coronary heart disease in postmenopausal women with diabetes: the Women's Health Initiative Observational Study. Diabetes Metab Res Rev 25:725-32
Hsia, Judith; Aragaki, Aaron; Bloch, Michael et al. (2004) Predictors of angina pectoris versus myocardial infarction from the Women's Health Initiative Observational Study. Am J Cardiol 93:673-8
Yasmeen, Shagufta; Romano, Patrick S; Pettinger, Mary et al. (2003) Frequency and predictive value of a mammographic recommendation for short-interval follow-up. J Natl Cancer Inst 95:429-36
Hsia, Judith; Barad, David; Margolis, Karen et al. (2003) Usefulness of prior hysterectomy as an independent predictor of Framingham risk score (The Women's Health Initiative). Am J Cardiol 92:264-9
Hendrix, Susan L; Clark, Amanda; Nygaard, Ingrid et al. (2002) Pelvic organ prolapse in the Women's Health Initiative: gravity and gravidity. Am J Obstet Gynecol 186:1160-6