The Women's Health Initiative is a randomized controlled clinical trial conducted in 40 clinical centers across the United States addressing some of the most common causes of death, disability, and impaired quality of life in postmenopausal women ages 50-79: cardiovascular disease; breast and colon cancer; and osteoporosis. The three components of this disease prevention trial are: (1) hormone replacement therapy with a primary outcomes of coronary heart disease and stroke and secondary outcomes of hip and other fractures; (2) low fat dietary intervention with primary outcomes of breast cancer and colorectal cancer and a secondary outcome of coronary heart disease; and (3) calcium and vitamin D supplementation with a primary outcome of hip fractures and secondary outcomes of colorectal cancer and combined fractures. A concurrent observational study will provide estimates of health effects of known risk factors and new predictors for disease. Each clinical center will collect data through questionnaires and biological specimens over 8-12 years.

Project Start
1994-09-30
Project End
2005-09-14
Budget Start
2000-09-27
Budget End
2001-09-30
Support Year
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612
Jo Hodonsky, Chani; Schurmann, Claudia; Schick, Ursula M et al. (2018) Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study. Am J Hematol :
Kato, Ikuko; Lane, Dorothy; Womack, Catherine R et al. (2017) Interaction between Nonsteroidal Anti-inflammatory Drugs and Low-fat Dietary Intervention on Colorectal Cancer Incidence; the Women's Health Initiative (WHI) Dietary Modification Trial. J Am Coll Nutr 36:462-469
Zaslavsky, Oleg; Woods, Nancy F; LaCroix, Andrea Z et al. (2016) Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study. J Am Geriatr Soc 64:831-7
Klimentidis, Yann C; Bea, Jennifer W; Thompson, Patricia et al. (2016) Genetic Variant in ACVR2B Is Associated with Lean Mass. Med Sci Sports Exerc 48:1270-5
Klimentidis, Y C; Arora, A; Chougule, A et al. (2016) FTO association and interaction with time spent sitting. Int J Obes (Lond) 40:411-6
Siegel, Rebecca L; Jacobs, Eric J; Newton, Christina C et al. (2015) Deaths Due to Cigarette Smoking for 12 Smoking-Related Cancers in the United States. JAMA Intern Med 175:1574-6
Gangwisch, James E; Hale, Lauren; Garcia, Lorena et al. (2015) High glycemic index diet as a risk factor for depression: analyses from the Women's Health Initiative. Am J Clin Nutr 102:454-63
Salmoirago-Blotcher, Elena; Hovey, Kathleen M; Andrews, Christopher A et al. (2015) Statin use and risk of haemorrhagic stroke in a community-based cohort of postmenopausal women: an observational study from the Women's Health Initiative. BMJ Open 5:e007075
Kato, Ikuko; Young, Alicia; Liu, Jingmin et al. (2015) Electric Blanket Use and Risk of Thyroid Cancer in the Women's Health Initiative Observational Cohort. Women Health 55:829-41
Jacobs, Eric J; Newton, Christina C; Carter, Brian D et al. (2015) What proportion of cancer deaths in the contemporary United States is attributable to cigarette smoking? Ann Epidemiol 25:179-182.e1

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