Objective: To test the safety and efficacy of aerosolized beta-2 adrenergic agonisttherapy (Albuterol Sulfate, USP) for improving clinical outcomes in patients with acutelung injury using a placebo controlled, double blinded randomized design. Hypothesis: Beta-2 adrenergic agonist therapy will improve clinical outcomes inpatients with acute lung injury (ALI). The potential mechanisms for improved outcomesinclude a decrease in pulmonary inflammation, reduction in lung endothelial andepithelial permeability, and enhanced resolution of alveolar edema.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR56170-4-0-2
Application #
7693923
Study Section
Project Start
2005-09-30
Project End
2012-09-29
Budget Start
Budget End
Support Year
Fiscal Year
2008
Total Cost
$120,988
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218