The contractor shall optimize the radioiodination reactions and test several difference radioiodinated conjugates for in vitro and in vivo stability. A comparison of a conventional (directly) radioiodinated antibody with the same antibody labeled using the radioiodinated conjugates, will be carried out. Studies using an iodine-131 labeled antibody will be conducted (in nude rats) to measure tissue dosimetry. The untimate goal of the study is to identify n antibody and a radioiodine conjugate that can become a commercial cancer therapy agent.

Project Start
1986-09-30
Project End
1988-09-29
Budget Start
1986-09-30
Budget End
1987-06-30
Support Year
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Neorx Corporation
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98119