The nervous system and neurotransmitters can significantly effect the function of the immune system. Recently, we have identified a novel CD4+ T-cell population that regulates innate immune function preventing mortality during septic shock. These unique T-cells exert regulatory function through production and release of the neurotransmitter of acetylcholine, inhibiting NF-?B dependent gene transcription in splenic macrophages. Release of this immuno-modulatory molecule is evoked by neurons that innervate the spleen, and release the neurotransmitter norepinephrine. Originally proposed to originate in the celiac ganglia, the anatomic origin of this splenic innervation has become highly controversial. The overall goals of this project are to refine the functional circuitry of communication between the nervous and immune systems. This will be achieved with mapping the origin of splenic sympathetic innervation using optogenetic stimulation of target ganglia with monitoring in target immune organs. Completion of these studies will yield important information in the basic immunological function of neuro-immune communication, providing a foundation for development of therapeutic devices.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Project #
3OT2OD023871-01S3
Application #
9788670
Study Section
Anatomical and Functional Mapping of the Innervation of Marjor Internal Organs (AFMI)
Program Officer
Qashu, Felicia M
Project Start
2017-02-01
Project End
2019-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Murray, K; Reardon, C (2018) The cholinergic anti-inflammatory pathway revisited. Neurogastroenterol Motil 30:
Reardon, Colin; Murray, Kaitlin; Lomax, Alan E (2018) Neuroimmune Communication in Health and Disease. Physiol Rev 98:2287-2316