Although cardiovascular structure and systolic and diastolic cardiac properties are altered in advanced age, the most striking and consistent observation is that these alterations are neither uniform nor inexorable. Thus, while the average heart undergoes mild hypertrophy, and evidences slowed and delayed relaxation at rest, and diminished performance during exercise stress, some do not. Although left ventricular mass, early diastolic filling, and exercise contractile performance changes are age-related, the relationship may not be due to aging alone but, in addition, to other factors which co-vary with age. If this is true, modification of these other factors may retard, inhibit, or even reverse previously described """"""""age-associated"""""""" changes. Excluding hypertension and ischemic heart disease, the most important of these are lifestyle factors, particularly physical activity status. The hypothesis of this proposal is that physical activity status has a significant modifying influence on previously described """"""""age-associated"""""""" cardiovascular alterations. The objective is to determine the extent to which altering physical activity status in lean elderly, disease-free individuals will alter their cardiac structure and function.
The specific aims of the proposal are to assess in elderly individuals without evidence of overt or latent cardiovascular disease the influence on cardiac structure and function of physical activity status, as indexed by maximal aerobic capacity, and changes in that status. Cardiac structure will be determined by magnetic resonance imaging and indexed by left ventricular mass, and regional left ventricular wall thickness and area. Cardiac function will be determined by using resting 2-D Echo and Doppler and resting and exercise gated blood pool scans and indexed by ejection fraction, cardiac output, left ventricular volumes, oxygen consumption, diastolic filling rates, and left ventricular systolic wall thickening. This proposal will therefore assess the impact of physical activity status on previously described """"""""age-associated"""""""" changes in cardiovascular structure and function in elderly, disease-free subjects.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Vaitkevicius, Peter V; Ebersold, Caroline; Shah, Muhammad S et al. (2002) Effects of aerobic exercise training in community-based subjects aged 80 and older: a pilot study. J Am Geriatr Soc 50:2009-13
Punjabi, Naresh M; Sorkin, John D; Katzel, Leslie I et al. (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165:677-82
Ferrara, C M; Goldberg, A P (2001) Limited value of the homeostasis model assessment to predict insulin resistance in older men with impaired glucose tolerance. Diabetes Care 24:245-9
Katzel, L I; Sorkin, J D; Fleg, J L (2001) A comparison of longitudinal changes in aerobic fitness in older endurance athletes and sedentary men. J Am Geriatr Soc 49:1657-64
Womack, C J; Harris, D L; Katzel, L I et al. (2000) Weight loss, not aerobic exercise, improves pulmonary function in older obese men. J Gerontol A Biol Sci Med Sci 55:M453-7
Goldberg, A P; Busby-Whitehead, M J; Katzel, L I et al. (2000) Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men. J Gerontol A Biol Sci Med Sci 55:M342-9
Katzel, L I; Sorkin, J D; Goldberg, A P (1999) Exercise-induced silent myocardial ischemia and future cardiac events in healthy, sedentary, middle-aged and older men. J Am Geriatr Soc 47:923-9
Berman, D M; Rogus, E M; Busby-Whitehead, M J et al. (1999) Predictors of adipose tissue lipoprotein lipase in middle-aged and older men: relationship to leptin and obesity, but not cardiovascular fitness. Metabolism 48:183-9
Hagberg, J M; Ferrell, R E; Katzel, L I et al. (1999) Apolipoprotein E genotype and exercise training-induced increases in plasma high-density lipoprotein (HDL)- and HDL2-cholesterol levels in overweight men. Metabolism 48:943-5
Bunyard, L B; Katzel, L I; Busby-Whitehead, M J et al. (1998) Energy requirements of middle-aged men are modifiable by physical activity. Am J Clin Nutr 68:1136-42

Showing the most recent 10 out of 77 publications