This Program Project (PPG) is a multidisciplinary effort dedicated to the study of Alzheimer's Disease (AD). This Project will be composed of Cores and five Individual Research Projects. A Clinical-Pathological Core will be responsible for recruiting 40 new African American and 40 new White AD patients and their families; continued longitudinal evaluations of two additional populations; the development and validation of a neuropsychological battery for patients with severe cognitive impairment; data management and analysis; arranging all autopsies; neuropathological diagnosis; and distributing and storing brain tissues. Individual Research Projects will investigate """"""""Special Population of AD Patients"""""""" and """"""""Synaptic Events and Their Relationship to Neuronal Death and Neuronal Plasticity."""""""" The project will continue to longitudinally assess African American and White AD caregivers and African American and White non-caregivers to determine racial differences in caregiving and to determine the effects of nursing home placement and bereavement on caregivers. The next will examine disturbances in phosphoinositide turnover in AD and control brains to characterize the specific biochemical abnormality and will examine the role of glucocorticoids in altering phosphoinositide turnover. The next project will examine a family of presynaptic proteins to determine their function in synaptogenesis and in AD. The next project will determine the role of intracellular calcium and oxidative metabolism in determining the phosphorylation state of tau. The next project utilizing a spontaneous neuronal reorganization occurring in the retrosplenial cortex, will examine the mechanisms mediating plasticity and learning deficiencies.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Neuroscience, Behavior and Sociology of Aging Review Committee (NBSA)
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University of Alabama Birmingham
Anatomy/Cell Biology
Schools of Medicine
United States
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Bambara, Jennifer K; Griffith, H Randall; Martin, Roy C et al. (2007) Medical decision-making abilities in older adults with chronic partial epilepsy. Epilepsy Behav 10:63-8
Huthwaite, Justin S; Martin, Roy C; Griffith, H Randall et al. (2006) Declining medical decision-making capacity in mild AD: a two-year longitudinal study. Behav Sci Law 24:453-63
Dresbach, Thomas; Torres, Viviana; Wittenmayer, Nina et al. (2006) Assembly of active zone precursor vesicles: obligatory trafficking of presynaptic cytomatrix proteins Bassoon and Piccolo via a trans-Golgi compartment. J Biol Chem 281:6038-47
Griffith, H R; Dymek, M P; Atchison, P et al. (2005) Medical decision-making in neurodegenerative disease: mild AD and PD with cognitive impairment. Neurology 65:483-5
Stevens, Alan; Owen, Jason; Roth, David et al. (2004) Predictors of time to nursing home placement in White and African American individuals with dementia. J Aging Health 16:375-97
van Groen, Thomas; Kadish, Inga; Wyss, J Michael (2004) Retrosplenial cortex lesions of area Rgb (but not of area Rga) impair spatial learning and memory in the rat. Behav Brain Res 154:483-91
Wyss, J Michael; Kadish, Inga; van Groen, Thomas (2003) Age-related decline in spatial learning and memory: attenuation by captopril. Clin Exp Hypertens 25:455-74
Roysommuti, S; Carroll, S L; Wyss, J M (2003) Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats. Neuroscience 121:779-85
Fenster, Steven D; Kessels, Michael M; Qualmann, Britta et al. (2003) Interactions between Piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones. J Biol Chem 278:20268-77
Kim, Seho; Ko, Jaewon; Shin, Hyewon et al. (2003) The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Biol Chem 278:6291-300

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