Aging and the Pathogenesis of Theiler's Virus Infection in Mice

Murray, Ronald S.

Abstract

B. Introduction This project propose to study the pathogenesis of Theiler's murine encephalitis virus (TMEV) in mice as a function of age. TMEV is an enterovirus and a natural pathogen of mice closely related to important human pathogens. The virus is known to establish persistent infection in mice and age appears to be a critical determinant of disease patterns. The information to be gathered during this study will potentially be of great benefit to our understanding and management of human diseases caused by enteroviruses. We propose to study the relationship of RNA virus pathogenesis and aging a different, yet equally challenging task as that of the DNA viral work being proposed.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Research Program Projects (P01)
• Project #: 5P01AG007347-02
• Application #: 3814121
• Support Year: 2
• Fiscal Year: 1989

Institution

• Name: University of Colorado Denver
• DUNS #: 065391526
• City: Aurora
• State: CO
• Country: United States
• Zip Code: 80045

Publications

Yang, Q; Sarnow, P (1997) Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions. Nucleic Acids Res 25:2800-7

Haller, A A; Sarnow, P (1997) In vitro selection of a 7-methyl-guanosine binding RNA that inhibits translation of capped mRNA molecules. Proc Natl Acad Sci U S A 94:8521-6

McBratney, S; Sarnow, P (1996) Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation. Mol Cell Biol 16:3523-34

Levin, M J; Murray, M; Zerbe, G O et al. (1994) Immune responses of elderly persons 4 years after receiving a live attenuated varicella vaccine. J Infect Dis 170:522-6

Hayward, A R; Buda, K; Levin, M J (1994) Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults. Viral Immunol 7:31-6

Zhang, Y; Cosyns, M; Levin, M J et al. (1994) Cytokine production in varicella zoster virus-stimulated limiting dilution lymphocyte cultures. Clin Exp Immunol 98:128-33

Hayward, A R; Zerbe, G O; Levin, M J (1994) Clinical application of responder cell frequency estimates with four years of follow up. J Immunol Methods 170:27-36

Mahalingam, R; Wellish, M; Lederer, D et al. (1993) Quantitation of latent varicella-zoster virus DNA in human trigeminal ganglia by polymerase chain reaction. J Virol 67:2381-4

Abzug, M J (1993) Identification of trophoblastic giant cells as the initial principal target of early gestational murine enterovirus infection. Placenta 14:137-48

Rotbart, H A; Levin, M J; Hayward, A R (1993) Immune responses to varicella zoster virus infections in healthy children. J Infect Dis 167:195-9