Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG008938-12
Application #
5204657
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Kleschevnikov, Alexander M; Belichenko, Pavel V; Faizi, Mehrdad et al. (2012) Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. J Neurosci 32:9217-27
Zhao, Yunfeng; Chaiswing, Luksana; Bakthavatchalu, Vasudevan et al. (2006) Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis 27:1692-8
Mansouri, Abdellah; Muller, Florian L; Liu, Yuhong et al. (2006) Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev 127:298-306
Zhao, Yunfent; Oberley, Terry D; Chaiswing, Luksana et al. (2002) Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene 21:3836-46
Huang, T T; Carlson, E J; Gillespie, A M et al. (2000) Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. J Gerontol A Biol Sci Med Sci 55:B5-9
Sago, H; Carlson, E J; Smith, D J et al. (2000) Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res 48:606-13
Akgur, F M; Brown, M F; Zibari, G B et al. (2000) Role of superoxide in hemorrhagic shock-induced P-selectin expression. Am J Physiol Heart Circ Physiol 279:H791-7
Freeman, B D; Reaume, A G; Swanson, P E et al. (2000) Role of CuZn superoxide dismutase in regulating lymphocyte apoptosis during sepsis. Crit Care Med 28:1701-8
Li, Y; Carlson, E; Murakami, K et al. (1999) Targeted expression of human CuZn superoxide dismutase gene in mouse central nervous system. J Neurosci Methods 89:49-55
Huang, T T; Carlson, E J; Raineri, I et al. (1999) The use of transgenic and mutant mice to study oxygen free radical metabolism. Ann N Y Acad Sci 893:95-112

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