Abstract

The Program Project entitled 'Anatomic, Physiologic and Cognitive Pathology of AD' brings together a number of basic scientists and clinicians who are based at different Chicago area universities. The project will be based at the Rush-Presbyterian-St. Luke's Medical Center. The proposed Program Project consists of administrative, clinical, neuropathology and statistical cores in addition to the following five research projects: 1) Electrophysiological Markers of Early Alzheimer's Disease (Leyla deToledo- Morrell and Frank Morrell, project leaders); 2) Knowledge Systems Analysis of Dementia in Early AD (John Gabrieli and Robert Wilson, project leaders; 3) Hippocampal Synaptic Connectivity in Alzheimer's Disease (Yuri Geinisman, project leader); 4) NGF Trophism in Alzheimer's Disease (Jeffrey Kordower, project leader; and 5) The Chemical Neuroanatomy of AD (Clifford Saper, project leader). Each core will support at least three of these research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG009466-03
Application #
3091270
Study Section
Aging Review Committee (AGE)
Project Start
1991-04-01
Project End
1996-03-31
Budget Start
1993-04-10
Budget End
1994-03-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612

  Publications

Mahady, Laura J; Perez, Sylvia E; Emerich, Dwaine F et al. (2017) Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain. J Comp Neurol 525:553-573
Cade, Brian E; Gottlieb, Daniel J; Lauderdale, Diane S et al. (2016) Common variants in DRD2 are associated with sleep duration: the CARe consortium. Hum Mol Genet 25:167-79
Mufson, Elliott J; Malek-Ahmadi, Michael; Perez, Sylvia E et al. (2016) Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment. Neurobiol Aging 37:147-153
Lim, Andrew S P; Bennett, David A; Buchman, Aron S (2016) Response to Letter Regarding Article, ""Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People"". Stroke 47:e175
Lim, Andrew S P; Yu, Lei; Schneider, Julie A et al. (2016) Sleep Fragmentation, Cerebral Arteriolosclerosis, and Brain Infarct Pathology in Community-Dwelling Older People. Stroke 47:516-8
Beckett, Laurel A; Donohue, Michael C; Wang, Cathy et al. (2015) The Alzheimer's Disease Neuroimaging Initiative phase 2: Increasing the length, breadth, and depth of our understanding. Alzheimers Dement 11:823-31
Sohail, Shahmir; Yu, Lei; Bennett, David A et al. (2015) Irregular 24-hour activity rhythms and the metabolic syndrome in older adults. Chronobiol Int 32:802-13
Alldred, Melissa J; Lee, Sang Han; Petkova, Eva et al. (2015) Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer's disease (AD). Brain Struct Funct 220:2983-96
Perez, Sylvia E; He, Bin; Nadeem, Muhammad et al. (2015) Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol Psychiatry 77:693-703
Ramanan, Vijay K; Risacher, Shannon L; Nho, Kwangsik et al. (2015) GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP. Brain 138:3076-88

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