The purpose of the Biostatistics/Data Management core is to develop, maintain and guarantee the integrity of the program project data base and to direct appropriate statistical analyses to address the scientific questions of the program.
The specific aims of the data management and biostatistics core are: 1. to create, manage and secure the project's data base; 2. to collaborate with project scientists in the design and analysis of the component studies; and 3. to develop new statistical methodology as necessary for valid and efficient inferences about project hypotheses. The data base will be created at the Johns Hopkins Wilmer Institute and maintained on a dedicated microcomputer with tape/cartridge backup. Questionnaires will be standardized, data entry will be verified and range- checked; monthly summary reports will be distributed to investigators; backups will be made weekly and one copy housed off-site. The statistical analysis will be conducted in three stages: exploration of univariate and multivariate empirical distributions of observed variables; statistical modelling of the relationship between observed responses and explanatory variables; and formal inferences which will take account of latent variables and measurement error. The first and second steps will be performed using the statistical packages S and SAS. The final step will use the program LISREL for continuous measures but will require methodologic and computer software development more generally.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Johns Hopkins University
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Zheng, D Diane; Bokman, Christine L; Lam, Byron L et al. (2016) Longitudinal relationships between visual acuity and severe depressive symptoms in older adults: the Salisbury Eye Evaluation study. Aging Ment Health 20:295-302
Zebardast, Nazlee; Swenor, Bonnielin K; van Landingham, Suzanne W et al. (2015) Comparing the Impact of Refractive and Nonrefractive Vision Loss on Functioning and Disability: The Salisbury Eye Evaluation. Ophthalmology 122:1102-10
Swenor, Bonnielin K; Muñoz, Beatriz; West, Sheila K (2014) A longitudinal study of the association between visual impairment and mobility performance in older adults: the salisbury eye evaluation study. Am J Epidemiol 179:313-22
Swenor, Bonnielin K; Bandeen-Roche, Karen; Muñoz, Beatriz et al. (2014) Does walking speed mediate the association between visual impairment and self-report of mobility disability? The Salisbury Eye Evaluation Study. J Am Geriatr Soc 62:1540-5
Christ, Sharon L; Zheng, D Diane; Swenor, Bonnielin K et al. (2014) Longitudinal relationships among visual acuity, daily functional status, and mortality: the Salisbury Eye Evaluation Study. JAMA Ophthalmol 132:1400-6
Storey, Philip; Munoz, Beatriz; Friedman, David et al. (2013) Racial differences in lens opacity incidence and progression: the Salisbury Eye Evaluation (SEE) study. Invest Ophthalmol Vis Sci 54:3010-8
Swenor, Bonnielin K; Muñoz, Beatriz; West, Sheila K (2013) Does visual impairment affect mobility over time? The Salisbury Eye Evaluation Study. Invest Ophthalmol Vis Sci 54:7683-90
Lee, Bryan S; Munoz, Beatriz E; West, Sheila K et al. (2013) Functional improvement after one- and two-eye cataract surgery in the Salisbury Eye Evaluation. Ophthalmology 120:949-55
Swenor, Bonnielin K; Bressler, Susan; Caulfield, Laura et al. (2010) The impact of fish and shellfish consumption on age-related macular degeneration. Ophthalmology 117:2395-401
Cross, J M; McGwin Jr, G; Rubin, G S et al. (2009) Visual and medical risk factors for motor vehicle collision involvement among older drivers. Br J Ophthalmol 93:400-4

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