Abstract

This program project grant, entitled """"""""Models of estrogen action in Alzheimer disease,"""""""" addresses age changes in brain cell responses to sex steroids that are pertinent to Alzheimer disease, with a focus on estradiol (E2). The five projects investigate components of the general pathway of E2 effects on astrocytes and neurons, using mice that lack sex steroid receptors or src. Project 1: Astrocytes, estradiol, and aging in hippocampal plasticity; C Finch and I Rozovsky Project 2: Estrogenic steroids: neurotrophic action and mechanism; R Brinton and T Berger Project 3: Sex hormones, synaptic plasticity, aging and stress; R Thompson and M Foy Project 4: Estrogen and glutamate receptors in plasticity and AD; M Baudry Project 5: Androgens and neuroprotection in AD models; C Pike Core A ( Finch) includes a Biostatistics Module and Database (D Lavond) for data obtained on the same animals by separate projects Core B (Animals, Finch) provides aging rodents of defined hormonal status (Sprague-Dawley rats; C57BL/6J mice) and genotyped mutant and knockout mice (Er-alpha-KO, Er-beta-KO, Tfm (mutant androgen receptor), and src-KO).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG014751-10
Application #
7115787
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M2))
Program Officer
Miller, Marilyn
Project Start
1997-09-01
Project End
2009-07-31
Budget Start
2006-08-01
Budget End
2009-07-31
Support Year
10
Fiscal Year
2006
Total Cost
$1,130,623
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
Organized Research Units
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M (2014) Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution. Gerontology 60:183-8
Baudry, M; Bi, X; Aguirre, C (2013) Progesterone-estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience 239:280-94
Kim, Soyun; Wang, Miao; Lee, Amy S et al. (2011) Impaired eyeblink conditioning in 78 kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice. Behav Neurosci 125:404-11
Kim, Soyun; Thompson, Richard F (2011) c-Fos, Arc, and stargazin expression in rat eyeblink conditioning. Behav Neurosci 125:117-23
Connor, S; Bloomfield, J; LeBoutillier, J C et al. (2009) Eyeblink conditioning leads to fewer synapses in the rabbit cerebellar cortex. Behav Neurosci 123:856-62
Zadran, Sohila; Qin, Qingyu; Bi, Xiaoning et al. (2009) 17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation. Proc Natl Acad Sci U S A 106:21936-41
Dominguez, Reymundo; Hu, Eric; Zhou, Miou et al. (2009) 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. J Neurosci 29:4228-38
Thompson, Richard F (2009) Habituation: a history. Neurobiol Learn Mem 92:127-34
Micevych, Paul; Dominguez, Reymundo (2009) Membrane estradiol signaling in the brain. Front Neuroendocrinol 30:315-27
Brinton, Roberta Diaz (2009) Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. Trends Pharmacol Sci 30:212-22

Showing the most recent 10 out of 54 publications