Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG017179-01
Application #
6334287
Study Section
Special Emphasis Panel (ZAG1-PKN-2 (M1))
Project Start
2000-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$241,231
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Chambers, Eric J; Price, Eric A; Bayramyan, Melina C et al. (2003) Computation of DNA backbone conformations. J Biomol Struct Dyn 21:111-25
Karanjawala, Zarir E; Hsieh, Chih-Lin; Lieber, Michael R (2003) Overexpression of Cu/Zn superoxide dismutase is lethal for mice lacking double-strand break repair. DNA Repair (Amst) 2:285-94
Hartenstine, Michael J; Goodman, Myron F; Petruska, John (2002) Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks. J Biol Chem 277:41379-89
Karanjawala, Zarir E; Adachi, Noritaka; Irvine, Ryan A et al. (2002) The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) 1:1017-26
Goodman, Myron F (2002) Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu Rev Biochem 71:17-50
Poltoratsky, V; Woo, C J; Tippin, B et al. (2001) Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc Natl Acad Sci U S A 98:7976-81
Rojsitthisak, P; Romero, R M; Haworth, I S (2001) Extrahelical cytosine bases in DNA duplexes containing d[GCC](n).d[GCC](n) repeats: detection by a mechlorethamine crosslinking reaction. Nucleic Acids Res 29:4716-23
Romero, R M; Rojsitthisak, P; Haworth, I S (2001) DNA interstrand crosslink formation by mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence. Arch Biochem Biophys 386:143-53
Karanjawala, Z E; Shi, X; Hsieh, C L et al. (2000) The mammalian FEN-1 locus: structure and conserved sequence features. Microb Comp Genomics 5:173-7
Hartenstine, M J; Goodman, M F; Petruska, J (2000) Base stacking and even/odd behavior of hairpin loops in DNA triplet repeat slippage and expansion with DNA polymerase. J Biol Chem 275:18382-90