This Program Project is a multi-disciplinary population-based study of centenarians in North Georgia. Our goal is to elucidate the roles of biological, psychological, and social factors that are pertinent to the survival and functioning of this population. We propose to develop and employ probability sampling frames to select representative samples of centenarians and younger control populations residing in a set of designated counties in Georgia. Projects 1 and 2 will focus on biomedical aging mechanisms among centenarians, including genetics and the relationship between cognitive function and neuropathology. Projects 3 and 4 will concentrate on psychosocial mechanisms, including studies of neuropsychologic correlates of functional capacity, and the impact of distal and proximal influences (such as life events and individual resources) on levels of adaptation among centenarians as reflected in behavioral skills and developmental outcomes. Synergy among and between Administrative Core will govern the Program Project activities; Core B will provide the sampling frame and ascertain subjects for all four projects; Core C will recruit and test all subjects for the Projects. Core D (Cell, Blood & DNA Bank) will process and distribute the blood for analysis of the Core Data and Projects 1 & 3. Core E will be responsible for the input of data, archiving, and comprehensive data management and statistical analysis activities for all four projects. In this way, the Program Project is designed to examine multi-disciplinary contributions to longevity and functioning of centenarians, maximizing interrelationships among biomedical and psychosocial factors.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program Projects (P01)
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Special Emphasis Panel (ZAG1-BJB-9 (O2))
Program Officer
Wagster, Molly V
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University of Georgia
Other Health Professions
Schools of Public Health
United States
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Toyoshima, Aya; Martin, Peter; Sato, Shinichi et al. (2018) The relationship between vision impairment and well-being among centenarians: findings from the Georgia Centenarian Study. Int J Geriatr Psychiatry 33:414-422
Lee, Kyuho; Holst, Marissa; Martin, Peter et al. (2018) Effect of Life Events, Social Supports, and Personality on Mental Status in Later Life. Int J Aging Hum Dev 86:111-130
Lee, Kyuho; Martin, Peter; Poon, Leonard W (2017) Predictors of caregiving burden: impact of subjective health, negative affect, and loneliness of octogenarians and centenarians. Aging Ment Health 21:1214-1221
Brodaty, Henry; Woolf, Claudia; Andersen, Stacy et al. (2016) ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol 16:52
Neltner, Janna H; Abner, Erin L; Jicha, Gregory A et al. (2016) Brain pathologies in extreme old age. Neurobiol Aging 37:1-11
Tanprasertsuk, Jirayu; Li, Binxing; Bernstein, Paul S et al. (2016) Relationship between Concentrations of Lutein and StARD3 among Pediatric and Geriatric Human Brain Tissue. PLoS One 11:e0155488
Cho, Jinmyoung; Martin, Peter; Poon, Leonard W et al. (2015) Successful aging and subjective well-being among oldest-old adults. Gerontologist 55:132-43
Davey, Adam; Siegler, Ilene C; Martin, Peter et al. (2015) Personality Structure Among Centenarians: The Georgia Centenarian Study. Exp Aging Res 41:361-85
Rahman-Filipiak, Annalise; Woodard, John L; Miller, L Stephen et al. (2015) Octogenarian and centenarian performance on the Fuld Object Memory Evaluation. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 22:438-51
Haslam, Alyson; Johnson, Mary Ann; Hausman, Dorothy B et al. (2014) Vitamin D status is associated with grip strength in centenarians. J Nutr Gerontol Geriatr 33:35-46

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