(from the application): Individuals differ in the degree to which they experience acute and chronic stress. The negative effects of such stress on health, especially mental health, are well established. Individuals also differ in their perceptions of social connectedness. Persons who feel unconnected report being """"""""lonely"""""""". Similar to stress, feelings of loneliness may have important negative effects on health. Furthermore, loneliness and stress may interact in their effects on health, so that loneliness impairs one? s ability to deal with chronic stress or to recover from stressful events. Theoretically, the social environment--household, family and neighborhood-- should affect levels of both loneliness and stress, although these relationships are relatively unexplored and poorly understood. Connections with family members should reduce loneliness and thus protect or improve health. Households provide the immediate context for individuals and bring with them both resources and demands. Imbalance in these resources and demands may influence stress, with consequent and subsequent ill effects on endocrine and immune systems and thus on health (see Projects 1 and 3). If households create the immediate context within which individuals function, households themselves are embedded in neighborhoods. A long tradition of research suggests that structural characteristics of neighborhoods shape the ways in which residents experience the neighborhood environment. Thus, the structural characteristics of the neighborhood may have important implications for individuals? perceptions of loneliness and stress. These perceptions may then in turn affect individuals? physical and mental health. We propose to examine the links between social environment, loneliness, stress, health, and disability among mature adults, in the framework of the conceptual model developed for this Program Project. We propose to use data from the Health and Retirement Study, a nationally representative, longitudinal survey of persons age 50 and above. We will use information from respondents? linked Medicare records to help characterize respondents? health. We will develop questions on loneliness, stress, and social support to be asked of a subsample of HRS respondents especially for this project. We will link characteristics of HRS respondents? census tracts to their individual data.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
1P01AG018911-01A1
Application #
6406064
Study Section
Special Emphasis Panel (ZAG1)
Project Start
2001-07-01
Project End
2006-06-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cacioppo, John T; Cacioppo, Stephanie (2018) The Population-Based Longitudinal Chicago Health, Aging, and Social Relations Study (CHASRS): Study Description and Predictors of Attrition in Older Adults. Arch Sci Psychol 6:21-31
Cole, Steven W; Capitanio, John P; Chun, Katie et al. (2015) Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation. Proc Natl Acad Sci U S A 112:15142-7
Cacioppo, John T; Cacioppo, Stephanie (2014) Social Relationships and Health: The Toxic Effects of Perceived Social Isolation. Soc Personal Psychol Compass 8:58-72
Luhmann, Maike; Hawkley, Louise C; Cacioppo, John T (2014) Thinking About One's Subjective Well-Being: Average Trends and Individual Differences. J Happiness Stud 15:757-781
Cacioppo, John T; Cacioppo, Stephanie; Boomsma, Dorret I (2014) Evolutionary mechanisms for loneliness. Cogn Emot 28:3-21
Caruso, M J; McClintock, M K; Cavigelli, S A (2014) Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats. Horm Behav 66:517-24
Powell, Nicole D; Sloan, Erica K; Bailey, Michael T et al. (2013) Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via ?-adrenergic induction of myelopoiesis. Proc Natl Acad Sci U S A 110:16574-9
Cacioppo, Stephanie; Couto, Blas; Bolmont, Mylene et al. (2013) Selective decision-making deficit in love following damage to the anterior insula. Curr Trends Neurol 7:15-19
VanderWeele, Tyler J; Hawkley, Louise C; Cacioppo, John T (2012) On the reciprocal association between loneliness and subjective well-being. Am J Epidemiol 176:777-84
Cacioppo, John T; Cacioppo, Stephanie (2012) The Phenotype of Loneliness. Eur J Dev Psychol 9:446-452

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