Age-related human diseases including cancer, Alzheimer's and Parkinson's disease show a clear correlation with mitochondrial dysfunction and reactive oxygen species (ROS). We propose to undertake a combined genetic, biochemical and bioenergetics approach to test the hypothesis that mitochondrial dysfunction and particularly mitochondrial reactive oxygen species (ROS) generation are causatively involved in age related disease. We propose to use three main manipulations of mitochondrial features-electron transport chain complexes, the glutathione pool and superoxide levels-and to measure outcomes models of these three age-related conditions. We believe that the proposed Program Project will make a significant contribution to our understanding of how mitochondrial function contributes to age-related disease with a view towards designing successful interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program Projects (P01)
Project #
5P01AG025901-03
Application #
7572836
Study Section
Special Emphasis Panel (ZAG1-ZIJ-2 (O2))
Program Officer
Wise, Bradley C
Project Start
2007-03-01
Project End
2012-02-29
Budget Start
2009-04-01
Budget End
2010-02-28
Support Year
3
Fiscal Year
2009
Total Cost
$1,577,939
Indirect Cost
Name
Buck Institute for Age Research
Department
Type
DUNS #
786502351
City
Novato
State
CA
Country
United States
Zip Code
94945
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Blaschko, Sarah D; Miller, Joe; Chi, Thomas et al. (2013) Microcomposition of human urinary calculi using advanced imaging techniques. J Urol 189:726-34

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