Abstract

This is a program in medical mycology. Each of the research projects contained in the program is concerned with an important area of medical mycology and is directed by an expert in that area. Although the program is divided into separate projects, they are interrelated and strengthened by this interaction. In effect, this is a coordinated approach to the objective of improving the outcome of systemic fungal infections. The projects in the program involve the following: 1. The molecular biology of growth and phase transition of the dimorphic pathogenic fungus Histoplasma capsulatum. 2. Development of new sensitive and specific diagnostic methods which will allow earlier diagnosis of systemic fungal infections. 3. Host fungal interactions which involve the role of humoral and cell mediated immune responses to pathogenic fungi. 4. Development of new forms of chemotherapy and more efficient use of the older agents. 5. A coordinated effort using the participants in the program to teach a modern approach to medical mycology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI016228-07
Application #
3091466
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1979-09-01
Project End
1989-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Lasker, B A; Page, L S; Lott, T J et al. (1992) Isolation, characterization, and sequencing of Candida albicans repetitive element 2. Gene 116:51-7
Lasker, B A; Page, L S; Lott, T J et al. (1991) Characterization of CARE-1: Candida albicans repetitive element-1. Gene 102:45-50
Wolf, J E; Stein, S H; Little, K D et al. (1991) Amphotericin B selectively stimulates macrophages from high responder mouse strains. Immunopharmacol Immunotoxicol 13:221-35
Brajtburg, J; Powderly, W G; Kobayashi, G S et al. (1990) Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34:183-8
Jullien, S; Brajtburg, J; Bolard, J (1990) Affinity of amphotericin B for phosphatidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparations. Biochim Biophys Acta 1021:39-45
Brajtburg, J; Powderly, W G; Kobayashi, G S et al. (1990) Amphotericin B: delivery systems. Antimicrob Agents Chemother 34:381-4
Spitzer, E D; Keath, E J; Travis, S J et al. (1990) Temperature-sensitive variants of Histoplasma capsulatum isolated from patients with acquired immunodeficiency syndrome. J Infect Dis 162:258-61
Jullien, S; Contrepois, A; Sligh, J E et al. (1989) Study of the effects of liposomal amphotericin B on Candida albicans, Cryptococcus neoformans, and erythrocytes by using small unilamellar vesicles prepared from saturated phospholipids. Antimicrob Agents Chemother 33:345-9
Spitzer, E D; Lasker, B A; Travis, S J et al. (1989) Use of mitochondrial and ribosomal DNA polymorphisms to classify clinical and soil isolates of Histoplasma capsulatum. Infect Immun 57:1409-12
Harris, G S; Keath, E J; Medoff, J (1989) Expression of alpha- and beta-tubulin genes during dimorphic-phase transitions of Histoplasma capsulatum. Mol Cell Biol 9:2042-9

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