The major objective of the Tulane ICIDR program is to continue its ongoing research program in Columbia, South America, with headquarters in Cali, which will address major public health problems of the country and neotropical region and which are of interest and importance to the scientific community in other parts of the world as well. A small satellite project of parallel studies will be conducted in the Republic of Haiti as well. The investigations will be carried out on a collaborative and interdisciplinary basis between American scientists and counterparts in the host countries. The proposed projects are directed toward basic biological, epidemiological and immunological investigations of selected, vector-borne parasitic disease of man including leishmaniasis, trypanosomiasis and filariasis. The Leishmania spp., Trypanosoma cruzi, Wuchereria bancrofti, Mansonella ozzardi, M. perstans, and Onchocerca volvulus are important or potential disease problems in the areas where the studies will be carried out. Investigative team members include medical parasitologists, entomologists, immunologists and medical clinicians. The studies, in the long-term, are aimed at gaining a more complete understanding of various aspects of these diseases which will contribute to their eventual control or eradication. The Colombian Fund for Scientific Research is the Colombian host and counterpart organization of the Tulane program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI016315-08
Application #
3091507
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Project Start
1980-06-01
Project End
1989-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
Schools of Public Health
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Travi, B L; Jaramillo, C; Montoya, J et al. (1994) Didelphis marsupialis, an important reservoir of Trypanosoma (Schizotrypanum) cruzi and Leishmania (Leishmania) chagasi in Colombia. Am J Trop Med Hyg 50:557-65
Weigle, K A; Santrich, C; Martinez, F et al. (1993) Epidemiology of cutaneous leishmaniasis in Colombia: a longitudinal study of the natural history, prevalence, and incidence of infection and clinical manifestations. J Infect Dis 168:699-708
Weigle, K A; Escobar, M; Arias, A L et al. (1993) A clinical prediction rule for American cutaneous leishmaniasis in Colombia. Int J Epidemiol 22:548-58
Weigle, K A; Santrich, C; Martinez, F et al. (1993) Epidemiology of cutaneous leishmaniasis in Colombia: environmental and behavioral risk factors for infection, clinical manifestations, and pathogenicity. J Infect Dis 168:709-14
Escobar, M A; Martinez, F; Scott Smith, D et al. (1992) American cutaneous and mucocutaneous leishmaniasis (tegumentary): a diagnostic challenge. Trop Doct 22 Suppl 1:69-78;63-4
Hitch, W L; Hightower, A W; Eberhard, M L et al. (1991) Analysis of isotype-specific antifilarial antibody levels in a Haitian pediatric population. Am J Trop Med Hyg 44:161-7
Martinez, J E; Travi, B L; Valencia, A Z et al. (1991) Metastatic capability of Leishmania (Viannia) panamensis and Leishmania (Viannia) guyanensis in golden hamsters. J Parasitol 77:762-8
Gutierrez, Y; Salinas, G H; Palma, G et al. (1991) Correlation between histopathology, immune response, clinical presentation, and evolution in Leishmania braziliensis infection. Am J Trop Med Hyg 45:281-9
Travi, B L; Orihel, T C; Montoya, J et al. (1990) Development of Mansonella perstans in the surrogate vector Aedes aegypti. Trop Med Parasitol 41:411-4
Saravia, N G; Weigle, K; Segura, I et al. (1990) Recurrent lesions in human Leishmania braziliensis infection--reactivation or reinfection? Lancet 336:398-402

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