Abstract

This Program Project deals with humoral and cellular studies of the IgA system in health and disease. The component projects include: studies of the immune response of normal and IgA deficient individuals to environmental antigens and the IgA effector functions relevant to an efficient disposal of circulating antigens and IgA immune complexes; prognostic factors in IgA renal diseases as related to the molecular forms of IgA, presence of circulating immune complexes, and deposited IgA subclasses and complement components; physicochemical properties of IgA rheumatoid factor and its potential role in the pathogenesis of acute inflammation and the development and function of IgA1 and IgA2 B cells in normal,, immunodeficient and leukemic individuals. The projects are listed as follows: Project I Serum and Secretory IgA Physiology and Immune Complexes. Project II IgA Renal Diseases. Project III Properties of IgA Rheumotoid Factor and Its Complexes. Project IV Role of IgA B Cells in Disease. These projects are interrelated at both conceptual and technical levels, because of the common interest of participating investigators in IgA physiology and immunopathology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI018745-05
Application #
3091528
Study Section
Allergy and Immunology Research Committee (AIRC)
Project Start
1982-09-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
School of Medicine & Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Renegar, Kathryn B; Menge, Alan; Mestecky, Jiri (2006) Influenza virus infection of the murine uterus: a new model for antiviral immunity in the female reproductive tract. Viral Immunol 19:613-22
Edwards, R P; Pitts, A; Crowley-Nowick, P et al. (1996) Immunoglobulin-containing plasma cells recruited to cervical neoplasia. Obstet Gynecol 87:520-6
Hunley, T E; Julian, B A; Phillips 3rd, J A et al. (1996) Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy. Kidney Int 49:571-7
Crowley-Nowick, P A; Campbell, E; Schrohenloher, R E et al. (1996) Polyethylene glycol precipitates of serum contain a large proportion of uncomplexed immunoglobulins and C3. Immunol Invest 25:91-101
Edwards, R P; Kuykendall, K; Crowley-Nowick, P et al. (1995) T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8-positive cells are recruited to invasion. Cancer 76:1411-5
Lue, C; Van den Wall Blake, A W; Prince, S J et al. (1995) Intraperitoneal administration of tetanus toxoid elicits a specific response of antibody-secreting cells in the peritoneal cavity. Adv Exp Med Biol 371A:103-6
Moldoveanu, Z; Russell, M W; Wu, H Y et al. (1995) Compartmentalization within the common mucosal immune system. Adv Exp Med Biol 371A:97-101
Moldoveanu, Z; Clements, M L; Prince, S J et al. (1995) Human immune responses to influenza virus vaccines administered by systemic or mucosal routes. Vaccine 13:1006-12
Taudorf, E; Moller, C; Russell, M W (1994) Secretory IgA response in oral immunotherapy. Investigation in birch pollinosis. Allergy 49:760-5
Husby, S; Mestecky, J; Moldoveanu, Z et al. (1994) Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J Immunol 152:4663-70

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