This is the first renewal of a Program Project that has been in effect for two years. It was originally submitted in order to study the molecular related to a number of devastating human conditions which have as their central feature an association with the with the major histocompatibility complex. Three investigators who have worked on both independent and collaborating projects relate to both clinical manifestations and such as insulin dependent diabetes mellitus and allergies as well as to basic 1-1. of T cell recognition and cellular proliferation wish to continue their integrated approach to these various human diseases. As previously, central core facilities are requested in order to centralize resources and technology and to more efficiently utilize personnel and funds. Each of the individual projects follows directly from the laboratory to the clinic and back to the research laboratory and should provide important insights into the pathogenesis of human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI023271-06
Application #
3091691
Study Section
Allergy & Clinical Immunology-1 (AITC)
Project Start
1986-07-01
Project End
1994-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
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Randen, I; Pascual, V; Victor, K et al. (1993) Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur J Immunol 23:1220-5
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Baisch, J M; Capra, J D (1993) Linkage disequilibrium within the HLA complex does not extend into HLA-DP. Scand J Immunol 37:499-503

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