Abstract

The overall goals of the program are to identify the viral and cellular factors involved in the establishment and reactivation of latent herpes simplex virus type 1 (HSV-1) infections using a mouse model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
5P01AI024010-03
Application #
3091757
Study Section
(SRC)
Project Start
1987-04-01
Project End
1992-03-31
Budget Start
1989-04-01
Budget End
1990-03-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Chen, Shih-Heng; Pearson, Angela; Coen, Donald M et al. (2004) Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment. J Virol 78:520-3
Kramer, M F; Chen, S H; Knipe, D M et al. (1998) Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. J Virol 72:1177-85
Pelosi, E; Mulamba, G B; Coen, D M (1998) Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants. Antiviral Res 37:17-28
Chen, S H; Cook, W J; Grove, K L et al. (1998) Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant. J Virol 72:6710-5
Pelosi, E; Rozenberg, F; Coen, D M et al. (1998) A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology 252:364-72
Horsburgh, B C; Chen, S H; Hu, A et al. (1998) Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? J Infect Dis 178:618-25
Chen, S H; Kramer, M F; Schaffer, P A et al. (1997) A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J Virol 71:5878-84
Frazier, D P; Cox, D; Godshalk, E M et al. (1996) The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells. J Virol 70:7424-32
Coen, D M (1996) Antiviral drug resistance in herpes simplex virus. Adv Exp Med Biol 394:49-57
Kanangat, S; Babu, J S; Knipe, D M et al. (1996) HSV-1-mediated modulation of cytokine gene expression in a permissive cell line: selective upregulation of IL-6 gene expression. Virology 219:295-300

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