Abstract

The proposed HIVRAD will consist of four interdigitating projects and two scientific cores that aredependent for success on the integrated scientific interaction among project leaders. For this reason, anadministrative core is proposed to assist Dr. Reinherz in communications between project leaders andmembers of their groups, both on-site (DFCI) and off-site (Children's Hospital, Harvard Medical School,Duke University Medical School and Iomai Coporation) as well as with various consultants. Because ofNIAID participation in collection and analysis of data and procedures required for submission of results toNIAID in evaluation of results from other centers that may be germane to the present undertaking, a wellorganizedadministrative component is essential. The core will facilitate all forms of communication withvarious project components (phone, email, fax, etc.). The budget will include funds for communicationcosts, clerical work and for national AIDS/HIVRAD meeting travel.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
3P01AI043649-09S2
Application #
7613723
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (55))
Project Start
2008-04-01
Project End
2009-01-31
Budget Start
2008-04-01
Budget End
2009-01-31
Support Year
9
Fiscal Year
2008
Total Cost
$135,672
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Tomaras, Georgia D; Montefiori, David C (2014) Spectrum of HIV antibodies in vaccine and disease. Curr Opin HIV AIDS 9:207-9
Hatfield, Stephen; Belikoff, Bryan; Lukashev, Dmitriy et al. (2009) The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. J Leukoc Biol 86:545-8
Song, Likai; Sun, Zhen-Yu J; Coleman, Kate E et al. (2009) Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. Proc Natl Acad Sci U S A 106:9057-62
Sun, Zhen-Yu J; Oh, Kyoung Joon; Kim, Mikyung et al. (2008) HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity 28:52-63
Kim, Mikyung; Qiao, Zhisong; Yu, Jessica et al. (2007) Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. Vaccine 25:5102-14
Kim, Mikyung; Qiao, Zhi-Song; Montefiori, David C et al. (2005) Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies. AIDS Res Hum Retroviruses 21:58-67
Reche, Pedro A; Zhang, Hong; Glutting, John-Paul et al. (2005) EPIMHC: a curated database of MHC-binding peptides for customized computational vaccinology. Bioinformatics 21:2140-1
Qiao, Zhi-Song; Kim, Mikyung; Reinhold, Bruce et al. (2005) Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. J Biol Chem 280:23138-46
Chen, Bing; Vogan, Erik M; Gong, Haiyun et al. (2005) Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure 13:197-211
Chen, Bing; Cheng, Yifan; Calder, Lesley et al. (2004) A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase. J Virol 78:4508-16

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