Abstract

A clinical resource core will be created to support the four projects. Serum, tissue, and clinical fungal isolates will be prospectively collected from a diverse group of patients with different types of Candida and Aspergillus infections. These specimens will be stored, characterized with clinical data, and a database for retrieval will be created for use by investigators of the four projects to characterize determinants of fungal virulence that are turned on in the course of various types of infection and pertinent host responses. Specimens will be made available to outside investigators to complement the program's objectives. Administrative support to the program project will also be provided.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program Projects (P01)
Project #
1P01AI061537-01
Application #
6841594
Study Section
Special Emphasis Panel (ZAI1-HSD-M (M2))
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2004-06-15
Budget End
2005-05-31
Support Year
1
Fiscal Year
2004
Total Cost
$44,341
Indirect Cost

  Institution

Name
University of Florida
Department
Type
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Cartmell, Jonathan; Paszkiewicz, Eugenia; Dziadek, Sebastian et al. (2015) Synthesis of antifungal vaccines by conjugation of ?-1,2 trimannosides with T-cell peptides and covalent anchoring of neoglycopeptide to tetanus toxoid. Carbohydr Res 403:123-34
Du, Chen; Wingard, John R; Cheng, Shaoji et al. (2012) Serum IgG responses against Aspergillus proteins before hematopoietic stem cell transplantation or chemotherapy identify patients who develop invasive aspergillosis. Biol Blood Marrow Transplant 18:1927-34
Nguyen, M Hong; Leather, Helen; Clancy, Cornelius J et al. (2011) Galactomannan testing in bronchoalveolar lavage fluid facilitates the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies and stem cell transplant recipients. Biol Blood Marrow Transplant 17:1043-50
Cutler, Jim E; Corti, Miriam; Lambert, Patrick et al. (2011) Horizontal transmission of Candida albicans and evidence of a vaccine response in mice colonized with the fungus. PLoS One 6:e22030
Vadnerkar, Aniket; Toyoda, Yoshiya; Crespo, Maria et al. (2011) Age-specific complications among lung transplant recipients 60 years and older. J Heart Lung Transplant 30:273-81
Vadnerkar, Aniket; Clancy, Cornelius J; Celik, Umit et al. (2010) Impact of mold infections in explanted lungs on outcomes of lung transplantation. Transplantation 89:253-60
Mitsani, Dimitra; Nguyen, M Hong; Kwak, Eun J et al. (2010) Cytomegalovirus disease among donor-positive/recipient-negative lung transplant recipients in the era of valganciclovir prophylaxis. J Heart Lung Transplant 29:1014-20
Mochon, A Brian; Jin, Ye; Ye, Jin et al. (2010) Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia. PLoS Pathog 6:e1000827
Vadnerkar, Aniket; Nguyen, M Hong; Mitsani, Dimitra et al. (2010) Voriconazole exposure and geographic location are independent risk factors for squamous cell carcinoma of the skin among lung transplant recipients. J Heart Lung Transplant 29:1240-4
Hao, Binghua; Clancy, Cornelius J; Cheng, Shaoji et al. (2009) Candida albicans RFX2 encodes a DNA binding protein involved in DNA damage responses, morphogenesis, and virulence. Eukaryot Cell 8:627-39

Showing the most recent 10 out of 26 publications