Abstract

The major aim of the Molecular Histology Core is to provide a specialized histologic service for investigators in the Program Project. Standard histomorphometry will be performed to characterize the disordered bone formation. Howship lacunae, osteoclast and osteoblast number, osteoid seam width, trabecular volume, the width of double bands from double tetracycline labeling, etc., will be measured.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program Projects (P01)
Project #
5P01AR038933-12
Application #
6201509
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Marijanovic, Inga; Kronenberg, Mark S; Erceg Ivkosic, Ivana et al. (2009) Comparison of proliferation and differentiation of calvarial osteoblast cultures derived from Msx2 deficient and wild type mice. Coll Antropol 33:919-24
Zhang, W; Pantschenko, A G; McCarthy, M-B et al. (2007) Bone-targeted overexpression of Bcl-2 increases osteoblast adhesion and differentiation and inhibits mineralization in vitro. Calcif Tissue Int 80:111-22
He, Jianing; Rosen, Clifford J; Adams, Douglas J et al. (2006) Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. Bone 38:826-35
Lengner, Christopher J; Steinman, Heather A; Gagnon, James et al. (2006) Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J Cell Biol 172:909-21
Delahunty, K M; Shultz, K L; Gronowicz, G A et al. (2006) Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology 147:3915-23
Sher, L B; Harrison, J R; Adams, D J et al. (2006) Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling. Calcif Tissue Int 79:118-25
Jiang, Jin; Lichtler, Alexander C; Gronowicz, Gloria A et al. (2006) Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling. Bone 39:494-504
Lee, Sun-Kyeong; Gardner, Amy E; Kalinowski, Judith F et al. (2006) RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production. Bone 38:678-85
Pantschenko, Alexander G; Zhang, Wenjian; Nahounou, Marcia et al. (2005) Effect of osteoblast-targeted expression of bcl-2 in bone: differential response in male and female mice. J Bone Miner Res 20:1414-29
Kim, Nacksung; Kadono, Yuho; Takami, Masamichi et al. (2005) Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med 202:589-95

Showing the most recent 10 out of 94 publications