Abstract

In order to test the potential advantages of improved dose distribution (helium) and both improved dose distribution and increased biological effect (neon, silicon, argon), a clinical trial is being conducted to study the therapeutic application of these heavy charged particles in the treatment of human cancers. Fractionated, large field, spread out Bragg peak charged particle radiotherapy treatment techniques are being continually refined together with improved techniques for assessment and compensation of tissue in homogeneities utilizing CT scanners to obtain tissue densities in the particle beam paths. Several pilot protocols with helium have been instituted, leading so far to one randomized trial: helium ion treatment plus 5-FU versus conventional radiation therapy plus 5-FU. We have also instituted Phase I-II pilot studies with heavier ions such as carbon, neon, and argon. Our ultimate goal is to test heavy charged particles against the best available therapy in a randomized trial of selected tumors. Existing cooperative study groups such as the Radiation Therapy Oncology Group and the Northern California Oncology Group are being utilized to facilitate these trials, together with the Bay Area Heavy Ion Association.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA019138-12
Application #
3092811
Study Section
(SRC)
Project Start
1976-06-30
Project End
1992-02-28
Budget Start
1987-09-30
Budget End
1989-02-28
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Lawrence Berkeley National Laboratory
Department
Type
Organized Research Units
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720

  Publications

Mishra, Kavita K; Quivey, Jeanne M; Daftari, Inder K et al. (2015) Long-term Results of the UCSF-LBNL Randomized Trial: Charged Particle With Helium Ion Versus Iodine-125 Plaque Therapy for Choroidal and Ciliary Body Melanoma. Int J Radiat Oncol Biol Phys 92:376-83
Mori, Shinichiro; Dong, Lei; Starkschall, George et al. (2014) A serial 4DCT study to quantify range variations in charged particle radiotherapy of thoracic cancers. J Radiat Res 55:309-19
Mori, Shinichiro; Wolfgang, John; Lu, Hsiao-Ming et al. (2008) Quantitative assessment of range fluctuations in charged particle lung irradiation. Int J Radiat Oncol Biol Phys 70:253-61
Mori, Shinichiro; Chen, George T Y (2008) Quantification and visualization of charged particle range variations. Int J Radiat Oncol Biol Phys 72:268-77
Mori, Shinichiro; Chen, George T Y; Endo, Masahiro (2007) Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy. Int J Radiat Oncol Biol Phys 69:308-17
Castro, J R; Linstadt, D E; Bahary, J P et al. (1994) Experience in charged particle irradiation of tumors of the skull base: 1977-1992. Int J Radiat Oncol Biol Phys 29:647-55
Kaplan, I D; Castro, J R; Phillips, T L (1994) Helium charged particle radiotherapy for meningioma: experience at UCLBL. University of California Lawrence Berkeley Laboratory. Int J Radiat Oncol Biol Phys 28:257-61
Schoenthaler, R; Phillips, T L; Castro, J et al. (1994) Carcinoma of the extrahepatic bile ducts. The University of California at San Francisco experience. Ann Surg 219:267-74
Blakely, E A; Daftari, I K; Meecham, W J et al. (1994) Helium-ion-induced human cataractogenesis. Adv Space Res 14:501-5
Petti, P L; Kessler, M L; Fleming, T et al. (1994) An automated image-registration technique based on multiple structure matching. Med Phys 21:1419-26

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