Abstract

The major emphasis of the proposed research is the investigation of several types of tumor viruses as model systems to study the molecular mechanism of transformation. The areas of investigation are as follows: I. Herpes Viruses: 1. Studies to identify the genes of herpes simplex virus which are required for transformation. 2) Studies of the genome of the Epstein-Barr virus. II. Papova Viruses: Isolation and characterization of promoter mutants of SV40 to study regulation of early gene expression. III. RNA Tumor Viruses: 1. Studies of endogenous viral genomes of uninfected chicken cells. 2. Studies of the transforming gene of feline sarcoma virus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA021082-10
Application #
3092910
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1977-09-30
Project End
1990-01-31
Budget Start
1986-02-01
Budget End
1987-01-31
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Dokhelar, M C; Pickford, H; Sodroski, J et al. (1989) HTLV-I p27rex regulates gag and env protein expression. J Acquir Immune Defic Syndr 2:431-40
Wolfes, H; Kogawa, K; Millette, C F et al. (1989) Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis. Science 245:740-3
Dokhelar, M C; Pickford, H; Sodroski, J et al. (1989) The potential for homeostatic regulation of the X region proteins of the human T cell leukemia virus type I. J Acquir Immune Defic Syndr 2:588-94
O'Keefe, S J; Wolfes, H; Kiessling, A A et al. (1989) Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg. Proc Natl Acad Sci U S A 86:7038-42
Fingeroth, J D; Benedict, M A; Levy, D N et al. (1989) Identification of murine complement receptor type 2. Proc Natl Acad Sci U S A 86:242-6
Cooper, G M; Goldman, D S; Kiessling, A A et al. (1988) The expression of oncogenes in germ cells. Prog Clin Biol Res 267:275-89
Austin, P J; Flemington, E; Yandava, C N et al. (1988) Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes. Proc Natl Acad Sci U S A 85:3678-82
Goldman, D S; Kiessling, A A; Cooper, G M (1988) Post-transcriptional processing suggests that c-mos functions as a maternal message in mouse eggs. Oncogene 3:159-62
Marchetti, M E; Smith, C A; Schaffer, P A (1988) A temperature-sensitive mutation in a herpes simplex virus type 1 gene required for viral DNA synthesis maps to coordinates 0.609 through 0.614 in UL. J Virol 62:715-21
Chen, C F; Corbley, M J; Roberts, T M et al. (1988) Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts. Science 239:1024-6

Showing the most recent 10 out of 28 publications