The purpose of the program is the coordination and implementation of the component parts of a broad program in cancer chemotherapy, i.e.: 1) Synthesis of anti-tumor compounds including vinca-like compounds, platinum compounds, cyclophosphazine derivatives, thymidylate synthetase inhibitors, and anthraquinone and anthracycline compounds; 2) testing of the compounds for their anti-tumor activity; 3) study of their toxicology, pharmacology and mechanisms of actions in animal systems; and 4) study, in humans, of their toxicology, clinical pharmacology and therapeutic activity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA024543-05
Application #
3093095
Study Section
(SRC)
Project Start
1979-03-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
Kimberly, P J; Huot, A; Hacker, M P (1992) Enhanced Ia expression by alveolar macrophages following intratracheal administration of bleomycin to rats. Immunol Invest 21:169-78
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Huot, A E; Gundel, R M; Hacker, M P (1990) Effect of erythrocytes on alveolar macrophage cytostatic activity induced by bleomycin lung damage in rats. Cancer Res 50:2351-5
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Janick-Buckner, D; Ranges, G E; Hacker, M P (1989) Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice. Toxicol Appl Pharmacol 100:465-73
Borman, L S; Kuehne, M E (1989) Specific alterations in the biological activities of C-20'-modified vinblastine congeners. Biochem Pharmacol 38:715-24
Branda, R F; McCormack, J J; Perlmutter, C A et al. (1988) Effects of folate deficiency on the metastatic potential of murine melanoma cells. Cancer Res 48:4529-34
Branda, R F; Carney, J K; Perlmutter, C A et al. (1987) Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate. Biochem Pharmacol 36:1605-12
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Webster, L K; Tong, W P; McCormack, J J (1987) Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers. J Pharm Pharmacol 39:942-4

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