Abstract

The purpose of the program is the coordination and implementation of the component parts of a broad program in cancer chemotherapy, i.e.: 1) Synthesis of anti-tumor compounds including vinca-like compounds, platinum compounds, cyclophosphazine derivatives, thymidylate synthetase inhibitors, and anthraquinone and anthracycline compounds; 2) testing of the compounds for their anti-tumor activity; 3) study of their toxicology, pharmacology and mechanisms of actions in animal systems; and 4) study, in humans, of their toxicology, clinical pharmacology and therapeutic activity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA024543-05
Application #
3093095
Study Section
(SRC)
Project Start
1979-03-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code

  Publications

Kimberly, P J; Huot, A; Hacker, M P (1992) Enhanced Ia expression by alveolar macrophages following intratracheal administration of bleomycin to rats. Immunol Invest 21:169-78
Huot, A E; Hacker, M P (1990) Role of reactive nitrogen intermediate production in alveolar macrophage-mediated cytostatic activity induced by bleomycin lung damage in rats. Cancer Res 50:7863-6
Huot, A E; Gundel, R M; Hacker, M P (1990) Effect of erythrocytes on alveolar macrophage cytostatic activity induced by bleomycin lung damage in rats. Cancer Res 50:2351-5
Janick-Buckner, D; Ranges, G E; Hacker, M P (1989) Effect of cytotoxic monoclonal antibody depletion of T-lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol Appl Pharmacol 100:474-84
Janick-Buckner, D; Ranges, G E; Hacker, M P (1989) Alteration of bronchoalveolar lavage cell populations following bleomycin treatment in mice. Toxicol Appl Pharmacol 100:465-73
Borman, L S; Kuehne, M E (1989) Specific alterations in the biological activities of C-20'-modified vinblastine congeners. Biochem Pharmacol 38:715-24
Branda, R F; McCormack, J J; Perlmutter, C A et al. (1988) Effects of folate deficiency on the metastatic potential of murine melanoma cells. Cancer Res 48:4529-34
Branda, R F; Carney, J K; Perlmutter, C A et al. (1987) Inhibition of lymphocyte nucleic acid metabolism and antibody production by trimetrexate. Biochem Pharmacol 36:1605-12
Roberts, J D; Stewart, J A; McCormack, J J et al. (1987) Phase I trial of tiazofurin administered by i.v. bolus daily for 5 days, with pharmacokinetic evaluation. Cancer Treat Rep 71:141-9
Webster, L K; Tong, W P; McCormack, J J (1987) Effect of trimethoprim, paracetamol and cimetidine on trimetrexate metabolism by rat perfused isolated livers. J Pharm Pharmacol 39:942-4

Showing the most recent 10 out of 17 publications