Abstract

The Core is concerned with support for the four projects in the Program Project. There are two main areas that will be supported. The Core will be responsible for design, synthesis and production of monoclonal antibodies and antibody fragments for use by all four projects. In addition, the Core provides centralized organization of the essential services for Projects 9 and 10 including equipment maintenance and computing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA027489-23
Application #
6570175
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Zhu, Xueyong; Tanaka, Fujie; Lerner, Richard A et al. (2009) Direct observation of an enamine intermediate in amine catalysis. J Am Chem Soc 131:18206-7
Kamikubo, Yuichi; Kroon, Gerard; Curriden, Scott A et al. (2006) The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule. Biochemistry 45:3297-306
Zhu, Xueyong; Wentworth Jr, Paul; Kyle, Robert A et al. (2006) Cofactor-containing antibodies: crystal structure of the original yellow antibody. Proc Natl Acad Sci U S A 103:3581-5
Steiner, Derek D; Mase, Nobuyuki; Barbas 3rd, Carlos F (2005) Direct asymmetric alpha-fluorination of aldehydes. Angew Chem Int Ed Engl 44:3706-10
Suri, Jeff T; Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Mimicking dihydroxy acetone phosphate-utilizing aldolases through organocatalysis: a facile route to carbohydrates and aminosugars. Org Lett 7:1383-5
Chowdari, Naidu S; Barbas 3rd, Carlos F (2005) Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter. Org Lett 7:867-70
Ramachary, Dhevalapally B; Barbas 3rd, Carlos F (2005) Direct amino acid-catalyzed asymmetric desymmetrization of meso-compounds: tandem aminoxylation/O-N bond heterolysis reactions. Org Lett 7:1577-80
Suri, Jeff T; Steiner, Derek D; Barbas 3rd, Carlos F (2005) Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands. Org Lett 7:3885-8
Tanaka, Fujie; Fuller, Roberta; Barbas 3rd, Carlos F (2005) Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity. Biochemistry 44:7583-92
Heine, Andreas; Luz, John G; Wong, Chi-Huey et al. (2004) Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. J Mol Biol 343:1019-34

Showing the most recent 10 out of 155 publications