The goal of the Biometry Core is to provide data management and computing support for all projects, and collaborate with project investigators in the development and application of statistical methods for design and analysis.
The specific aims of the Biometry Core are: 1. To provide statistical collaboration in the design, execution and analysis of all projects. 2. To develop procedures for data collection and maintain computer databases for information storage and retrieval. 3. To provide interim reports on individual study progress. 4. To interpret the statistical and prevention literature relevant to all projects, and to develop new study design and analysis procedures for skin cancer research. The biostatistical and data management support offered by the Biometry Core is essential to the successful completion of the proposed studies. A detailed assessment of sample size requirements and constraints has been considered during the design of all studies to assure adequate statistical power to detect effects of biological and clinical importance. Data collection and quality control procedures have been designed to reduce sources of extraneous variation, which could otherwise mandate large sample sizes. Statistical expertise has been central to the proper analysis and interpretation of past experimental results, and will continue to have a central role in the studies proposed in this competitive renewal.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA027502-18
Application #
6269107
Study Section
Project Start
1998-09-18
Project End
1999-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Blohm-Mangone, Karen; Burkett, Nichole B; Tahsin, Shekha et al. (2018) Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice. Cancer Prev Res (Phila) 11:265-278
Knights-Mitchell, Shellie S; Romanowski, Marek (2018) Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes. Nanotheranostics 2:295-305
Roh, Eunmiri; Lee, Mee-Hyun; Zykova, Tatyana A et al. (2018) Targeting PRPK and TOPK for skin cancer prevention and therapy. Oncogene 37:5633-5647
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Yamamoto, Hiroyuki; Ryu, Joohyun; Min, Eli et al. (2017) TRAF1 Is Critical for DMBA/Solar UVR-Induced Skin Carcinogenesis. J Invest Dermatol 137:1322-1332
Zykova, Tatyana A; Zhu, Feng; Wang, Lei et al. (2017) The T-LAK Cell-originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis. EBioMedicine 18:73-82
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Gao, Ge; Zhang, Tianshun; Wang, Qiushi et al. (2017) ADA-07 Suppresses Solar Ultraviolet-Induced Skin Carcinogenesis by Directly Inhibiting TOPK. Mol Cancer Ther 16:1843-1854
Janda, Jaroslav; Burkett, Nichole B; Blohm-Mangone, Karen et al. (2016) Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-?B and AP-1 Signaling in Keratinocytes and Mouse Skin. Photochem Photobiol 92:816-825
Peng, C; Zeng, W; Su, J et al. (2016) Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. Oncogene 35:1170-9

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