Abstract

The principal effort of this grant deals with a further elucidation of the role short-acting estrogens play in breast cancer, the interactions of potent, short-acting and anti-estrogens with specific receptors, and methods of modulating these interactions with chemical probes to elucidate the nature and function of these reactions. The characterization of a human androgen binding protein will be undertaken and its possible role in cancer examined. Other studies deal with the role serum 5SBG might have in the etiology of breast cancer and the characterization of glucocorticoid and histamine receptors and their possible relation to certain types of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA028856-06
Application #
3093255
Study Section
Cancer Special Program Advisory Committee (CAK)
Project Start
1981-02-01
Project End
1987-04-30
Budget Start
1986-02-01
Budget End
1987-04-30
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Bronson, R E; Calaman, S D; Traish, A M et al. (1987) Stimulation of lysyl oxidase (EC 1.4.3.13) activity by testosterone and characterization of androgen receptors in cultured calf aorta smooth-muscle cells. Biochem J 244:317-23
Muller, R E; Traish, A M (1986) The role of lysyl, arginyl, and sulfhydryl residues in estrogen receptor activation, 4S to 5S dimerization, and conversion of receptor from a state with low affinity into a state with higher affinity for estrogen. Ann N Y Acad Sci 464:202-17
Traish, A M; Muller, R E; Wotiz, H H (1986) Binding of 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues. Endocrinology 118:1327-33
Traish, A M; Williams, D F; Wotiz, H H (1986) Binding of (3H)7 alpha,17 alpha-dimethyl-19-nortestosterone (mibolerone) to progesterone receptors: comparison with binding of (3H)R5020 and (3H)ORG2058. Steroids 47:157-73
Traish, A M; Muller, R E; Wotiz, H H (1985) Interaction of cyproterone acetate with rat prostatic androgen receptors. Steroids 45:247-62
Traish, A M; Muller, R E; Wotiz, H H (1985) A new exchange procedure for the quantitation of prostatic androgen receptor complexes formed in vivo. J Steroid Biochem 23:405-13
Traish, A M; Muller, R E; Williams, D F et al. (1985) Changes in the sedimentation properties of cytosolic androgen receptors associated with activation in vitro and in vivo. Steroids 46:929-46
Traish, A M; Muller, R E; Wotiz, H H (1985) Resolution of non-activated and activated androgen receptors based on differences in their hydrodynamic properties. J Steroid Biochem 22:601-9
Muller, R E; Traish, A M; Wotiz, H H (1985) Interaction of estradiol and estriol with uterine estrogen receptor in vivo and in excised uteri or cell suspensions at 37 C: noncooperative estradiol binding and absence of estriol inhibition of estradiol-induced receptor activation and transformation. Endocrinology 117:1839-47
Muller, R E; Traish, A M; Hirota, T et al. (1985) Conversion of estrogen receptor from a state with low affinity for estradiol into a state of higher affinity does not require 4S to 5S dimerization. Endocrinology 116:337-45