Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA029545-05
Application #
4691226
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Hahnemann University
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Suhadolnik, R J; Reichenbach, N L; Hitzges, P et al. (1994) Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome. In Vivo 8:599-604
Gillespie, D; Hubbell, H R; Carter, W A et al. (1994) Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements. In Vivo 8:375-81
Hubbell, H R; Kariko, K; Suhadolnik, R J et al. (1994) RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia. Anticancer Res 14:341-6
Suhadolnik, R J; Reichenbach, N L; Hitzges, P et al. (1994) Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome. Clin Infect Dis 18 Suppl 1:S96-104
Hubbell, H R; Gibson, G D; Bigler, R D (1992) Potentiated lymphokine-activated killer cell activity generated by low-dose interleukin-2 and mismatched double-stranded RNA. Cancer Immunol Immunother 34:259-64
Hubbell, H R; Vargas, H E; Tsujimoto, K L et al. (1992) Antitumor effects of interleukin-2 and mismatched double-stranded RNA, individually and in combination, against a human malignant melanoma xenograft. Cancer Immunol Immunother 35:151-7
Muller, W E; Weiler, B E; Charubala, R et al. (1991) Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry 30:2027-33
Hubbell, H R; Boyer, J E; Roane, P et al. (1991) Cyclic AMP mediates the direct antiproliferative action of mismatched double-stranded RNA. Proc Natl Acad Sci U S A 88:906-10
Hubbell, H R; Sheetz, P C; Iogal, S S et al. (1991) Heterogeneous nuclear RNA from hairy cell leukemia patients activates 2',5'-oligoadenylate synthetase. Anticancer Res 11:1927-32
Morgan, D A; Gumucio, D L; Brodsky, I (1991) Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02. Blood 78:2860-71

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