Abstract

The research proposed is a broadly based Program Project based on proved strengths in engineering and physics, biology, and clinical research in hyperthermia. Seven interrelated and interdependent research projects and a supporting Core are requested with the overall objective to study hyperthermia in a systematic fashion in order to further define its role in clinical care of patients with cancer. The research is focused on the following objectives. l. To explore certain biological effects of hyperthermia (alone or with S-irradiation and selected drugs which have potential clinical application) through studies designed: a) to explain basic mechanisms, b) to provide background information in animal models for future clinical application, and c) to provide preliminary clinical data through Phase I and II pilot studies. 2. To explore improved methods of hyperthermia (equipment, treatment techniques, thermometry, and treatment planning) as applied to investigational hyperthermia treatment of patients with cancer. 3. To participate in quality assurance programs as they become available and selected Phase III clinical trials sponsored by national cooperative groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
2P01CA029578-07
Application #
3093301
Study Section
Clinical Cancer Program Project Review Committee (CCP)
Project Start
1981-04-01
Project End
1990-12-31
Budget Start
1988-03-01
Budget End
1988-12-31
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Ruslander, D A; Gebhard, D H; Tompkins, M B et al. (1997) Immunophenotypic characterization of canine lymphoproliferative disorders. In Vivo 11:169-72
Shaw, J A; Durney, C H; Christensen, D A (1991) Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain method. IEEE Trans Biomed Eng 38:861-70
Sapozink, M D; Joszef, G; Astrahan, M A et al. (1990) Adjuvant pelvic hyperthermia in advanced cervical carcinoma. I. Feasibility, thermometry and device comparison. Int J Hyperthermia 6:985-96
Yasui, L S; Fink, T J (1990) Thermal sensitivity of CHO cells with different shapes. Int J Hyperthermia 6:57-65
Sapozink, M D; Gibbs, P; Gibbs Jr, F A et al. (1988) Myonecrosis following deep pelvic hyperthermia. Int J Hyperthermia 4:251-8
Peck, J W; Joyner, D E; Gibbs Jr, F A (1988) RIF-1 tumor treatment in anesthetized mice with minimal effects on blood flow and hypoxia. Radiat Res 114:105-13
Warters, R L; Brizgys, L M (1987) Apurinic site induction in the DNA of cells heated at hyperthermic temperatures. J Cell Physiol 133:144-50
Rowley, R; Joyner, D E; Stewart, J R (1987) In vitro response to hyperthermia or X-irradiation of diploid and tetraploid RIF-1 cells separated by centrifugal elutriation. Int J Hyperthermia 3:235-44
Peck, J W; Gibbs Jr, F A (1987) Assay of premorbid murine jejunal fibrosis based on mechanical changes after X irradiation and hyperthermia. Radiat Res 112:525-43
Sapozink, M D (1986) The application of thermal dose in clinical trials. Int J Hyperthermia 2:157-64

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