Tobacco smoking is causally associated with cancer of the lung, upper aerodigestive tract, pancreas, kidney, and urinary bladder and is associated with cancer of the liver, uterine cervix and with leukemia. Involuntary smoking gives rise to some risk of cancer. Tobacco chewing, especially snuff dipping, is causally associated with cancer of the oral cavity and pharynx. Tobacco smoke and its particulate matter are carcinogenic in mice, rats and hamsters. Snuff is tumorigenic in the oral cavity of rats. It is the overall goal of the Program Project to contribute to an understanding of the carcinogenicity of tobacco smoke and of smokeless tobacco and to elucidate the mechanisms involved in the development of tumors induced by tobacco carcinogenesis. Five projects are proposed. 1. Study of the activation of tobacco-specific nitrosamines (TSNA) in humans and human risk assessment by measuring adducts of the carcinogenic TSNA, PAH and aromatic amines with DNA and with globin. 2. Analysis of tobacco for nitrosamino acids, cigarette smoke analysis for aromatic and heterocyclic amines and for nitrohydrocarbons, environmental tobacco smoke analysis for 3-venylpyridine. Cervical mucus will be examined for alkaloids and TSNA. 7. Study of the carcinogenesis of smokeless tobacco and betel quid. 10. Study of the mechanisms of the carcinogenic effects of tobacco smoke carcinogenic effects of tobacco smoke carcinogens in the oral cavity and esophagus of humans. 5. Development of biomarkers in smokers for the uptake of benzene.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA029580-13
Application #
2087949
Study Section
Special Emphasis Panel (SRC (K1))
Project Start
1981-06-15
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
Boffetta, Paolo; Jayaprakash, Vijayvel; Yang, Ping et al. (2011) Tobacco smoking as a risk factor of bronchioloalveolar carcinoma of the lung: pooled analysis of seven case-control studies in the International Lung Cancer Consortium (ILCCO). Cancer Causes Control 22:73-9
Mitacek, Eugene J; Brunnemann, Klaus D; Suttajit, Maitree et al. (2008) Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, and nitrosodimethylamine. Nutr Cancer 60:196-203
Prokopczyk, Bogdan; Hoffmann, Dietrich; Bologna, Matthew et al. (2002) Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol 15:677-85
Mitacek, E J; Brunnemann, K D; Suttajit, M et al. (1999) Exposure to N-nitroso compounds in a population of high liver cancer regions in Thailand: volatile nitrosamine (VNA) levels in Thai food. Food Chem Toxicol 37:297-305
Hoffmann, D; Djordjevic, M V; Hoffmann, I (1997) The changing cigarette. Prev Med 26:427-34
Djordjevic, M V; Hoffmann, D; Hoffmann, I (1997) Nicotine regulates smoking patterns. Prev Med 26:435-40
Carmella, S G; Borukhova, A; Desai, D et al. (1997) Evidence for endogenous formation of tobacco-specific nitrosamines in rats treated with tobacco alkaloids and sodium nitrite. Carcinogenesis 18:587-92
Melikian, A A; Sun, P; Pierpont, C et al. (1997) Gas chromatographic-mass spectrometric determination of benzo[a]pyrene and chrysene diol epoxide globin adducts in humans. Cancer Epidemiol Biomarkers Prev 6:833-9
Richie Jr, J P; Carmella, S G; Muscat, J E et al. (1997) Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers. Cancer Epidemiol Biomarkers Prev 6:783-90
Prokopczyk, B; Cox, J E; Hoffmann, D et al. (1997) Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers. J Natl Cancer Inst 89:868-73

Showing the most recent 10 out of 114 publications