Tobacco smoking is causally associated with cancer of the lung, upper aerodigestive tract, pancreas, kidney, and urinary bladder and is associated with cancer of the liver, uterine cervix and with leukemia. Involuntary smoking gives rise to some risk of cancer. Tobacco chewing, especially snuff dipping, is causally associated with cancer of the oral cavity and pharynx. Tobacco smoke and its particulate matter are carcinogenic in mice, rats and hamsters. Snuff is tumorigenic in the oral cavity of rats. It is the overall goal of the Program Project to contribute to an understanding of the carcinogenicity of tobacco smoke and of smokeless tobacco and to elucidate the mechanisms involved in the development of tumors induced by tobacco carcinogenesis. Five projects are proposed. 1. Study of the activation of tobacco-specific nitrosamines (TSNA) in humans and human risk assessment by measuring adducts of the carcinogenic TSNA, PAH and aromatic amines with DNA and with globin. 2. Analysis of tobacco for nitrosamino acids, cigarette smoke analysis for aromatic and heterocyclic amines and for nitrohydrocarbons, environmental tobacco smoke analysis for 3-venylpyridine. Cervical mucus will be examined for alkaloids and TSNA. 7. Study of the carcinogenesis of smokeless tobacco and betel quid. 10. Study of the mechanisms of the carcinogenic effects of tobacco smoke carcinogenic effects of tobacco smoke carcinogens in the oral cavity and esophagus of humans. 5. Development of biomarkers in smokers for the uptake of benzene.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA029580-13
Application #
2087949
Study Section
Special Emphasis Panel (SRC (K1))
Project Start
1981-06-15
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595
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Mitacek, Eugene J; Brunnemann, Klaus D; Suttajit, Maitree et al. (2008) Geographic distribution of liver and stomach cancers in Thailand in relation to estimated dietary intake of nitrate, nitrite, and nitrosodimethylamine. Nutr Cancer 60:196-203
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Koppang, N; Rivenson, A; Dahle, H K et al. (1997) A study of tobacco carcinogenesis, LIII: carcinogenicity of N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustela vison). Cancer Lett 111:167-71
Hoffmann, D; Djordjevic, M V (1997) Chemical composition and carcinogenicity of smokeless tobacco. Adv Dent Res 11:322-9
Stellman, S D; Muscat, J E; Thompson, S et al. (1997) Risk of squamous cell carcinoma and adenocarcinoma of the lung in relation to lifetime filter cigarette smoking. Cancer 80:382-8
Hoffmann, D; Djordjevic, M V; Hoffmann, I (1997) The changing cigarette. Prev Med 26:427-34

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