Abstract

Bone marrow malignancies of B-cell lineage will be investigated by clinical and laboratory methods to define their evolution and management. Neoplasms diagnosed and managed using unified criteria and treatment protocols will be serially investigated for genotypic and phenotypic heterogeneity and secondary change, (clonal evolution), and the relationship of these changes to the clinical course of the disease, including response to treatment will be assessed. Treatments with cytotoxic drugs, biological response modifiers, and immunological reagents will be developed, assayed in vitro for efficacy and safety, and subsequently those with anti-neoplastic potential will be prepared for, and tested in clinical phase I and phase II trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA042683-02
Application #
3093929
Study Section
(SRC)
Project Start
1987-09-05
Project End
1990-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Roswell Park Cancer Institute Corp
Department
Type
DUNS #
City
Buffalo
State
NY
Country
United States
Zip Code
14263

  Publications

Seon, Ben K; Haba, Akinao; Matsuno, Fumihiko et al. (2011) Endoglin-targeted cancer therapy. Curr Drug Deliv 8:135-43
Evans, S S; Collea, R P; Leasure, J A et al. (1993) IFN-alpha induces homotypic adhesion and Leu-13 expression in human B lymphoid cells. J Immunol 150:736-47
Mayhew, E; Vaughan, L; Panus, A et al. (1993) Lipid-associated methylpheophorbide-a (hexyl-ether) as a photodynamic agent in tumor-bearing mice. Photochem Photobiol 58:845-51
Evans, S S; Wang, W C; Gregorio, C C et al. (1993) Interferon-alpha alters spectrin organization in normal and leukemic human B lymphocytes. Blood 81:759-66
Kawata, A; Han, T; Dadey, B et al. (1993) Establishment and characterization of the tumors of chronic lymphocytic leukemia cell line in nude and SCID mice. Leuk Res 17:883-94
Bernstein, Z P; Fitzpatrick, J E; O'Donnell, A et al. (1992) Clinical significance of monoclonal proteins in chronic lymphocytic leukemia. Leukemia 6:1243-5
Scarozza, A M; Collins, T J; Evans, S S (1992) DNA synthesis in nuclei isolated from Daudi B cells: a model to study the antiproliferative mechanisms of interferon-alpha. J Interferon Res 12:35-42
Islam, A; Glomski, C; Henderson, E S (1992) Endothelial cells and hematopoiesis: a light microscopic study of fetal, normal, and pathologic human bone marrow in plastic-embedded sections. Anat Rec 233:440-52
Henderson, B W; Dougherty, T J (1992) How does photodynamic therapy work? Photochem Photobiol 55:145-57
Takeuchi, T; Barcos, M P; Seon, B K (1991) Monoclonal antibody SN10 which shows a highly selective reactivity with human B leukemia-lymphoma and is effectively internalized into cells. Cancer Res 51:2985-93

Showing the most recent 10 out of 21 publications