Abstract

Radiolabeled immunoglobulin therapy (RIT) produces partial and complete regression of cancer in some patients. Analyses of clinical trials and experimental data suggest specific areas of research to improve this therapy and extend its applications to a wider spectrum of malignancies. We now propose to study RIT in a detailed and coordinated research program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA043791-03
Application #
3094074
Study Section
Cancer Therapeutics Program Project Review Committee (CTR)
Project Start
1987-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1991-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Quadri, S M; Vriesendorp, H M (1998) Effects of linker chemistry on the pharmacokinetics of radioimmunoconjugates. Q J Nucl Med 42:250-61
Vriesendorp, H M; Quadri, S M; Jaeckle, K A et al. (1996) Proposal for translational analysis and development of clinical radiolabeled immunoglobulin therapy. Radiother Oncol 41:151-61
Quadri, S M; Malik, A B; Chu, H B et al. (1996) Intraperitoneal indium-111- and yttrium-90-labeled human IgM (AC6C3-2B12) in nude mice bearing peritoneal carcinomatosis. J Nucl Med 37:1545-51
Vriesendorp, H M; Morton, J D; Quadri, S M (1995) Review of five consecutive studies of radiolabeled immunoglobulin therapy in Hodgkin's disease. Cancer Res 55:5888s-5892s
Quadri, S M; Siddiqui, A; Klein, J L et al. (1995) Biodistribution and tumor localization of 111In-labeled unmodified and modified F(ab')2 fragments of human monoclonal IgM (16.88) in a nude mouse model. Nucl Med Biol 22:413-23
Quadri, S M; Malik, A B; Tang, X Z et al. (1995) Preclinical analysis of intraperitoneal administration of 111In-labeled human tumor reactive monoclonal IgM AC6C3-2B12. Cancer Res 55:5736s-5742s
Dillehay, L E; Mayer, R; Zhang, Y G et al. (1995) Prediction of tumor response to experimental radioimmunotherapy with 90Y in nude mice. Int J Radiat Oncol Biol Phys 33:417-27
Mayer, R; Dillehay, L E; Shao, Y et al. (1995) Direct measurement of intratumor dose-rate distributions in experimental xenografts treated with 90Y-labeled radioimmunotherapy. Int J Radiat Oncol Biol Phys 32:147-57
Siddiqui, A; Quadri, S M; Griffiths, G L et al. (1995) Tumor targeting and pharmacokinetics of unmodified and modified F(ab)2 fragments of an anti-CEA murine monoclonal antibody (Immu-14). Nucl Med Biol 22:425-35
Herpst, J M; Klein, J L; Leichner, P K et al. (1995) Survival of patients with resistant Hodgkin's disease after polyclonal yttrium 90-labeled antiferritin treatment. J Clin Oncol 13:2394-400

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