This Program Project Grant is focused on the applications of monoclonal antibodies (mAbs) for therapy of gastrointestinal (GI) cancer. Preclinical studies will focus on anti-idiotype mAb vaccines. The specific objectives of the individual research projects are the following: 1. Generation of anti-idiotype antibodies for GI carcinoma. 2. Determining the avidities of anti- idiotype mAbs, determine the DNA and protein sequences, generate computer models for idiotope determining loops, sequence and synthesize the peptides, as the first step towards clinical trials. 3. Clinical trial for GI cancer with an anti-idiotype mAb (anti- 8019).
| Bhattacharya-Chatterjee, Malaya; Chatterjee, Sunil K; Foon, Kenneth A (2002) Anti-idiotype antibody vaccine therapy for cancer. Expert Opin Biol Ther 2:869-81 |
| Bhattacharya-Chatterjee, M; Chatterjee, S K; Foon, K A (2001) The anti-idiotype vaccines for immunotherapy. Curr Opin Mol Ther 3:63-9 |
| Bhattacharya-Chatterjee, M; Chatterjee, S K; Foon, K A (2000) Anti-idiotype vaccine against cancer. Immunol Lett 74:51-8 |
| Bhattachary-Chatterjee, M; Nath Baral, R; Chatterjee, S K et al. (2000) Counterpoint. Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine. Cancer Immunol Immunother 49:133-41 |
| Bhattacharya-Chatterjee, M; Foon, K A (1998) Anti-idiotype antibody vaccine therapies of cancer. Cancer Treat Res 94:51-68 |
| Chakraborty, M; Mukerjee, S; Foon, K A et al. (1995) Induction of human breast cancer-specific antibody responses in cynomolgus monkeys by a murine monoclonal anti-idiotype antibody. Cancer Res 55:1525-30 |
| Chakraborty, M; Foon, K A; Kohler, H et al. (1995) Preclinical evaluation in nonhuman primates of an anti-idiotypic antibody that mimicks the carcinoembryonic antigen. J Immunother Emphasis Tumor Immunol 18:95-103 |
| Foon, K A; Chakraborty, M; John, W J et al. (1995) Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J Clin Invest 96:334-42 |
