Gene Therapy for Chronic Myelogenous Leukemia

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Program Projects (P01)
• Project #: 1P01CA059348-04
• Application #: 2338973
• Support Year: 4
• Fiscal Year: 1995

Institution

• Name: Indiana University-Purdue University at Indianapolis
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Jakacki, R I; Jamison, C; Mathews, V P et al. (1998) Dose-intensification of procarbazine, CCNU (lomustine), vincristine (PCV) with peripheral blood stem cell support in young patients with gliomas. Med Pediatr Oncol 31:483-90

Traycoff, C M; Orazi, A; Ladd, A C et al. (1998) Proliferation-induced decline of primitive hematopoietic progenitor cell activity is coupled with an increase in apoptosis of ex vivo expanded CD34+ cells. Exp Hematol 26:53-62

Veena, P; Traycoff, C M; Williams, D A et al. (1998) Delayed targeting of cytokine-nonresponsive human bone marrow CD34(+) cells with retrovirus-mediated gene transfer enhances transduction efficiency and long-term expression of transduced genes. Blood 91:3693-701

Meikrantz, W; Bergom, M A; Memisoglu, A et al. (1998) O6-alkylguanine DNA lesions trigger apoptosis. Carcinogenesis 19:369-72

Traycoff, C M; Halstead, B; Rice, S et al. (1998) Chronic myelogenous leukaemia CD34+ cells exit G0/G1 phases of cell cycle more rapidly than normal marrow CD34+ cells. Br J Haematol 102:759-67

Jakacki, R I; Jamison, C; Heifetz, S A et al. (1997) Feasibility of sequential high-dose chemotherapy and peripheral blood stem cell support for pediatric central nervous system malignancies. Med Pediatr Oncol 29:553-9

Veena, P; Cornetta, K; Davidson, A et al. (1997) Preferential sequestration in vitro of BCR/ABL negative hematopoietic progenitor cells among cytokine nonresponsive CML marrow CD34+ cells. Bone Marrow Transplant 19:1213-21

Maze, R; Kapur, R; Kelley, M R et al. (1997) Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA. J Immunol 158:1006-13

Traycoff, C M; Srour, E F; Dutt, P et al. (1997) The 30/35 kDa chymotryptic fragment of fibronectin enhances retroviral-mediated gene transfer in purified chronic myelogenous leukemia bone marrow progenitors. Leukemia 11:159-67

Braun, S E; McIvor, R S; Davidson, A S et al. (1997) Retrovirally mediated gene transfer of Arg22 and Tyr22 forms of dihydrofolate reductase into the hematopoietic cell line K562: a comparison of methotrexate resistance. Cancer Gene Ther 4:26-32