Abstract

Core B is designed to provide support to the projects by standardizing common methods and resources, ensuring consistency and quantitative accuracy across the Program Project. Each service of the Core is relevant to and will be utilized by each project. The goals of Core B are six fold:
Specific Aim 1 : To provide a centralized repository of cell lines, media, and collected serum for each project.
Specific Aim 2 : To perform wide-field and conformal irradiation of small animals using preclinical and clinical radiotherapy systems.
Specific Aim 3 : To perform multimodal imaging of small animals using preclinical systems for positron emission tomography (PET), x-ray computed tomography (CT), and bioluminescence imaging (BLI).
Specific Aim 4 : To perform histopathologic analysis of tissue specimens collected from experimental animal models.
Specific Aim 5 : To perform quantitative analysis of imaging data collected through the other Specific Aims.
Specific Aim 6 : To provide statistical support to the projects of the P01.

Public Health Relevance

Core B, the Translational Biology core ofthis program project, provides support to the projects for maintenance and standardization of cell lines and shared resources, as well as in the execution of common methods including animal radiotherapy and imaging, histopathology, data quantitation, and statistical analysis. These are essential services that are common to all projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
4P01CA067166-19
Application #
9121476
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
19
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304

  Publications

Vilalta, Marta; Brune, Jourdan; Rafat, Marjan et al. (2018) The role of granulocyte macrophage colony stimulating factor (GM-CSF) in radiation-induced tumor cell migration. Clin Exp Metastasis 35:247-254
Tandon, Neha; Thakkar, Kaushik N; LaGory, Edward L et al. (2018) Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Bio Protoc 8:
Yang, Zhifen; Zhang, Jing; Jiang, Dadi et al. (2018) A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1?-XBP1 Activation. Mol Cancer Res 16:745-753
Benej, Martin; Hong, Xiangqian; Vibhute, Sandip et al. (2018) Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A 115:10756-10761
Rafat, Marjan; Aguilera, Todd A; Vilalta, Marta et al. (2018) Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Res 78:4241-4252
Saiki, Julie P; Cao, Hongbin; Van Wassenhove, Lauren D et al. (2018) Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes. Proc Natl Acad Sci U S A 115:6279-6284
Olcina, Monica M; Kim, Ryan K; Melemenidis, Stavros et al. (2018) The tumour microenvironment links complement system dysregulation and hypoxic signalling?. Br J Radiol :20180069
Castellini, Laura; Moon, Eui Jung; Razorenova, Olga V et al. (2017) KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res 45:3674-3692
VandeKopple, Matthew J; Wu, Jinghai; Baer, Lisa A et al. (2017) Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol 235:27-38
Peinado, Héctor; Zhang, Haiying; Matei, Irina R et al. (2017) Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer 17:302-317

Showing the most recent 10 out of 203 publications