Abstract

) The Adenovirus Core will generate the proposed recombinant adenoviruses for each of the individual projects, including screening of clones and limited characterization in vitro. Selected adenoviruses will be grown in medium scale production and purified to be used for the proposed in vitro and in vivo studies. Testing for replication competent adenoviruses (RCA) will be performed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA072955-02
Application #
6203413
Study Section
Project Start
1999-08-01
Project End
2000-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Biddlestone-Thorpe, Laura; Marchi, Nicola; Guo, Kathy et al. (2012) Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents. Adv Drug Deliv Rev 64:605-13
Cardnell, Robert J G; Mikkelsen, Ross B (2011) Nitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenografts. PLoS One 6:e20147
Hawkins, Amy J; Golding, Sarah E; Khalil, Ashraf et al. (2011) DNA double-strand break - induced pro-survival signaling. Radiother Oncol 101:13-7
Dever, Seth M; Golding, Sarah E; Rosenberg, Elizabeth et al. (2011) Mutations in the BRCT binding site of BRCA1 result in hyper-recombination. Aging (Albany NY) 3:515-32
Khalil, Ashraf; Morgan, Rhiannon N; Adams, Bret R et al. (2011) ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle 10:481-91
Bayden, Alexander S; Yakovlev, Vasily A; Graves, Paul R et al. (2011) Factors influencing protein tyrosine nitration--structure-based predictive models. Free Radic Biol Med 50:749-62
Adams, Bret R; Golding, Sarah E; Rao, Raj R et al. (2010) Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. PLoS One 5:e10001
Yakovlev, Vasily A; Bayden, Alexander S; Graves, Paul R et al. (2010) Nitration of the tumor suppressor protein p53 at tyrosine 327 promotes p53 oligomerization and activation. Biochemistry 49:5331-9
Yakovlev, Vasily A; Rabender, Christopher S; Sankala, Heidi et al. (2010) Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). Int J Radiat Oncol Biol Phys 78:547-54
Hawkins, Amy J; Subler, Mark A; Akopiants, Konstantin et al. (2009) In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation. DNA Repair (Amst) 8:654-63

Showing the most recent 10 out of 108 publications