Abstract

The vector core will support all of the individual projects in this application. The vector core will make highly purified and well characterized adenovirus vectors for the investigator's projects. These viruses include a bcl-xs adenovirus, a hrk adenovirus, and an mbm-2 adenovirus. These viruses will be used in basic studies to analyze the programmed cell death pathways in cancer cells that arise from the breast, the ovaries, the bladder and hematopoietic cells. These viruses will also be used in animal models to test the potential of these viruses as gene therapy agents. Finally, the bcl-xs adenovirus will be produced by this vector core for clinical trials in breast cancer and ovarian cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA075136-03
Application #
6300557
Study Section
Project Start
2000-04-12
Project End
2001-01-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$198,353
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Bockhorn, Jessica; Dalton, Rachel; Nwachukwu, Chika et al. (2013) MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun 4:1393
Dontu, Gabriela; Abdallah, Wissam M; Foley, Jessica M et al. (2003) In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17:1253-70
Al-Hajj, Muhammad; Wicha, Max S; Benito-Hernandez, Adalberto et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100:3983-8
Hernandez-Alcoceba, Ruben; Pihalja, Michael; Qian, Dalong et al. (2002) New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther 13:1737-50
Taj, M M; Tawil, R J; Engstrom, L D et al. (2001) Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. Prostate 47:194-204
Kielb, S J; Shah, N L; Rubin, M A et al. (2001) Functional p53 mutation as a molecular determinant of paclitaxel and gemcitabine susceptibility in human bladder cancer. J Urol 166:482-7
Hernandez-Alcoceba, R; Pihalja, M; Nunez, G et al. (2001) Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells. Cancer Gene Ther 8:298-307
Sanz, C; Benito, A; Inohara, N et al. (2000) Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells. Blood 95:2742-7
Hernandez-Alcoceba, R; Pihalja, M; Wicha, M S et al. (2000) A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors. Hum Gene Ther 11:2009-24
Sumantran, V N; Lee, D S; Woods Ignatoski, K M et al. (2000) A bcl-xS adenovirus selectively induces apoptosis in transformed cells compared to normal mammary cells. Neoplasia 2:251-60

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