The Radiation Core will provide the irradiation facilities in support of all of the projects in the program. This core is housed Richardson Laboratories of the Department of Radiation Oncology and currently consists of three irradiators, a J.L. Shepherd Mark I, Model 30, Cesium Irradiator, a J.L. Shepherd Mark I, Model 68A, Cesium Irradiator and a Philips RT-250 orthovoltage irradiator. The cesium irradiators are specifically designed for experimental gamma-irradiations. They contain 2,200 Ci/137 Cs sources. Tissue culture flasks are irradiated by stacking them on the rotating platform. A special tube holder can accommodate test tubes with volumes up to 50 ml. The cesium irradiators are suitable for the majority of the irradiations required by this program; however, orthovoltage machine serves as both a back-up for the cesium sources and as a sources for irradiation at variable energies. Dr. Bengt Bjarngard is Director of the Radiation Core. His responsibilities include training personnel in the proper and safe use of the instruments and ensuring compliance with NRC regulations. Dr. Bjarngard chairs an Internal Advisory Committee. The Committee meets as needed to set rules and policies for instrument use and to make decisions concerning maintenance and repairs. The Committee guarantees fair and equitable use of the instruments among the investigators.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
5P01CA075138-04
Application #
6470074
Study Section
Project Start
2001-06-29
Project End
2002-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2001
Total Cost
$140,673
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Qayum, Naseer; Im, Jaehong; Stratford, Michael R et al. (2012) Modulation of the tumor microvasculature by phosphoinositide-3 kinase inhibition increases doxorubicin delivery in vivo. Clin Cancer Res 18:161-9
Higgins, Geoff S; Prevo, Remko; Lee, Yin-Fai et al. (2010) A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Res 70:2984-93
Dorsey, Jay F; Mintz, Akiva; Tian, Xiaobing et al. (2009) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel have cooperative in vivo effects against glioblastoma multiforme cells. Mol Cancer Ther 8:3285-95
Hamilton, Julie; Grawenda, Anna M; Bernhard, Eric J (2009) Phosphatase inhibition and cell survival after DNA damage induced by radiation. Cancer Biol Ther 8:1577-86
Hamilton, Julie; Higgins, Geoff; Bernhard, Eric J (2009) Conventional radiotherapy or hypofractionation? A study of molecular changes resulting from different radiation fractionation schemes. Cancer Biol Ther 8:774-6
Qayum, Naseer; Muschel, Ruth J; Im, Jae Hong et al. (2009) Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res 69:6347-54
Al-Assar, Osama; Muschel, Ruth J; Mantoni, Tine S et al. (2009) Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers. Int J Radiat Oncol Biol Phys 75:1216-25
Mantoni, Tine S; Schendel, Roy R E; Rodel, Franz et al. (2008) Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma. Cancer Biol Ther 7:1806-15
Plastaras, John P; Dorsey, Jay F; Carroll, Kristina et al. (2008) Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer Biol Ther 7:2047-53
Finnberg, Niklas; Wambi, Chris; Ware, Jeffrey H et al. (2008) Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo. Cancer Biol Ther 7:2023-33

Showing the most recent 10 out of 98 publications