Dizziness, vertigo, motion sickness, and simulator sickness are common clinical problems rooted in abnormal perception of movement. Clinical testing of the vestibular system and understanding of vestibular physiology has historically focused on reflex function and perception of isolated vestibular stimuli. However, vestibular reflex function is poorly correlated with perceptual symptoms. Perception of self-motion is at the root of understanding navigation, dizziness, motion sickness, and simulator sickness. Self-motion perception is also multi-sensory and primarily involves the vestibular and visual systems, although auditory and proprioception also may play a role in some situations. In many common clinical disorders, perceptual testing is the first line of clinical investigation. For instance an evaluation of vision usually begins with having the patient report what they are able to see and evaluation of hearing begins with testing what the patient is able to hear. However, understanding of self-motion perception is not yet at a state where perceptual testing is clinically meaningful. Most of the previous work on vestibular perception has focused on unimodal stimuli of perceptual thresholds and tests of visual vertical which do not address the more complex multisensory situations in which self-motion is usually experienced. The current proposal aims to advance understanding of human motion perception into a clinically and physiologically relevant arena by examining this perception in an appropriate, multisensory context. The project will measure visual-vestibular integration and define the conditions where it occurs. Visual motion can be ambiguously interpreted as self-motion through a fixed environment, environmental motion relative to a fixed observer, or inaccurate sensory calibration. The project will examine all of these possibilities but determining the factors involved in determining common causation which is essential for knowing if visual motion is a result of self-motion and can be integrated with vestibular cues or is the result of external motion and should be segregated. The project will also look at mechanism adaptation in two contexts ? exposure to consistently offset visual and inertial stimuli and exposure to a rotating environment. This will be examined in normal controls but also individuals with unilateral loss of vestibular function. Developing a method of adaptation that is effective in vestibular pathology will be helpful in developing tools that are potential methods of future vestibular rehabilitation.

Public Health Relevance

Heading perception is determined from visual and vestibular cues which must be integrated to determine self-motion within an environment. This is this proposal seeks to better understand these phenomena which are likely factors in dizziness and motion sickness.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
Project #
Application #
Study Section
Sensorimotor Integration Study Section (SMI)
Program Officer
Poremba, Amy
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Rochester
School of Medicine & Dentistry
United States
Zip Code
Crane, Benjamin T; Schubert, Michael C (2018) An adaptive vestibular rehabilitation technique. Laryngoscope 128:713-718
Rodriguez, Raul; Crane, Benjamin Thomas (2018) Effect of vibration during visual-inertial integration on human heading perception during eccentric gaze. PLoS One 13:e0199097
Crane, Benjamin T (2017) Effect of eye position during human visual-vestibular integration of heading perception. J Neurophysiol 118:1609-1621
Lin, E P; Crane, B T (2017) The Management and Imaging of Vestibular Schwannomas. AJNR Am J Neuroradiol 38:2034-2043
Crane, Benjamin T (2016) Perception of combined translation and rotation in the horizontal plane in humans. J Neurophysiol 116:1275-85
Miller, Mark A; Crane, Benjamin T (2016) Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine. World J Otorhinolaryngol Head Neck Surg 2:175-180
Kushner, Bradley; Allen, Paul D; Crane, Benjamin T (2016) Frequency and Demographics of Gentamicin Use. Otol Neurotol 37:190-5
Crane, Benjamin T (2016) Why no Unilateral Vestibular Atelectasis? Otol Neurotol 37:115
Miller, Mark A; Kesarwani, Priya; Crane, Benjamin T (2016) Autophony in a Patient With Giant Cell Tumor of the Temporal Bone. Otol Neurotol 37:e238-9
Rosenblatt, Steven David; Crane, Benjamin Thomas (2015) Influence of Visual Motion, Suggestion, and Illusory Motion on Self-Motion Perception in the Horizontal Plane. PLoS One 10:e0142109

Showing the most recent 10 out of 11 publications