Abstract

Core component B will grow human xenograft tumors selected by Project 1 and conduct standard high-dose rate and low-dose-rate therapies, and measure the resulting regrowth delays. The results will be used by Project 1 to test hypotheses concerning how the time-course of irradiation interacts with characteristics of different tumor cell lines to determine tumor responses. The standard high-dose-rate therapies will be a single 10 Gy fraction or two fractionated protocols in which most radiation is given either early or late in the treatment. The standard low-doze treatments will be made with either one or two injections of 125I-labeled immunomicrospheres prepared by Project 3 to meet the treatment conditions required by Project 1. Later in the project, high- and low-dose rate treatments will be used in combination. Core B will monitor tumor retention by trace-labeling the preparations with 131I and using an external detector. Tumor dose rate distributions produced by the injections will be measured using radiochromic medium. Based on these measurements, Core B will work with project 1 to calculate how the resulting dose patterns and different models of cellular sensitivity would affect tumor response. Core B will also grow tumors and make the necessary injections for hypoxia measurements to be made by Project 2.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Program Projects (P01)
Project #
1P01CA079862-01A1
Application #
6135301
Study Section
Project Start
1999-07-01
Project End
2000-04-30
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Williams, Jerry R; Zhang, Yonggang; Zhou, Haoming et al. (2011) Sequentially-induced responses define tumour cell radiosensitivity. Int J Radiat Biol 87:628-43
Williams, Jerry R; Zhang, Yonggang; Zhou, Haoming et al. (2010) Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo. Radiat Oncol 5:71
Williams, Jerry R; Zhang, Yonggang; Zhou, Haoming et al. (2008) A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status. Int J Radiat Biol 84:253-64
Williams, Jerry R; Zhang, Yonggang; Zhou, Haoming et al. (2008) Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation. Int J Radiat Oncol Biol Phys 72:909-17
Williams, Jerry R; Zhang, Yonggang; Zhou, Haoming et al. (2008) Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution. Int J Radiat Biol 84:151-64
Fang, Ning; Tan, Wee Jin; Leong, Kam W et al. (2005) pH responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface. Colloids Surf B Biointerfaces 42:245-52
Tan, Wee Jin; Teo, Gilbert P; Liao, Kin et al. (2005) Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface. Biomaterials 26:891-8
Acs, Geza; Chen, Mei; Xu, Xiaowei et al. (2004) Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells. Cancer Lett 214:243-51
Chan, Vincent; Liu, Kuo-Kang; Le Visage, Catherine et al. (2004) Bioadhesive characterization of poly(methylidene malonate 2.12) microparticle on model extracellular matrix. Biomaterials 25:4327-32
Pan, Yi; Oprysko, Patricia R; Asham, Andrew M et al. (2004) p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 23:4975-83

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