Abstract

This is an application for a Program Project to study the basic human neuroscience of cocaine action. We propose a coherent and highly integrated group of studies based on functional magnetic resonance imaging (fMRI) of human subjects and animal models. The basic scientific goals of the study are to (1) understand the circuitry in humans that underlies cocaine induced euphoria, withdrawal dysphoria and cocaine- conditioned craving, (2) to investigate differences in regional brain activation by cocaine in nondependent versus dependent users. In order to take full advantage of the strengths of fMRI, one aspect of the program involves technical development of this tool, optimizing its ability to image cortical and subcortical structures hypothesized to play key roles in the human brain reward circuitry. Animal models are used in the program because they are necessary to interpret the biological significance of human fMRI data and to relate it well validated molecular models of cocaine-induced neural activation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA009467-04
Application #
2517948
Study Section
Special Emphasis Panel (SRCD (50))
Project Start
1994-09-30
Project End
1999-07-31
Budget Start
1997-09-30
Budget End
1998-07-31
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Makris, N; Kennedy, D N; Boriel, D L et al. (2010) Methods of MRI-based structural imaging in the aging monkey. Methods 50:166-77
Kennedy, David N; Haselgrove, Christian; Makris, Nikos et al. (2010) WebParc: a tool for analysis of the topography and volume of stroke from MRI. Med Biol Eng Comput 48:215-28
Liu, Christina H; Greve, Doug N; Dai, Guangping et al. (2007) Remifentanil administration reveals biphasic phMRI temporal responses in rat consistent with dynamic receptor regulation. Neuroimage 34:1042-53
Choi, Ji-Kyung; Mandeville, Joseph B; Chen, Y Iris et al. (2006) High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging. Synapse 60:152-7
Choi, Ji-Kyung; Chen, Y Iris; Hamel, Edith et al. (2006) Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage 30:700-12
Chen, Yin-Ching I; Choi, Ji-Kyung; Andersen, Susan L et al. (2005) Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging. Psychopharmacology (Berl) 180:705-15
Talavage, Thomas M; Edmister, Whitney B (2004) Nonlinearity of FMRI responses in human auditory cortex. Hum Brain Mapp 22:216-28
Mandeville, Joseph B; Jenkins, Bruce G; Chen, Yin-Ching I et al. (2004) Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn Reson Med 52:1272-81
Elman, Igor; Lukas, Scott E; Karlsgodt, Katherine H et al. (2003) Acute cortisol administration triggers craving in individuals with cocaine dependence. Psychopharmacol Bull 37:84-9
Zaharchuk, G; Yamada, M; Sasamata, M et al. (2000) Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction. J Cereb Blood Flow Metab 20:1341-51

Showing the most recent 10 out of 17 publications