The absorption of fluoride in a variety of infant foods has been determined by measuring the amount of fluoride remaining in the upper segment of the gastrointestinal tract of large rats 6 hours after force feeding food containing a known amount of fluoride to animals starved for 16 hours. The """"""""blank"""""""" for the model system consisting of residual fluoride in the upper gastrointestinal tract of starved animals and fluoride contributed by the diffusion cell and reagents was 0.147 +/- 0.0197 Mug. Mean values for the percent of the fluoride absorbed from infant foods thus far investigated ranged from 87.4 to 99.5%. Contrary to the results of other investigators the bioavailability of fluoride in low concentration from milk was found to be 96.5% using this model system. The bioavailability of fluoride from milk products and adult foods is also being investigated.

Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Nopakun, J; Guo, M K; Messer, H H et al. (1988) Fluoride redeposition and retention during bone turnover in lactating rats. J Dent Res 67:1213-6
Guo, M K; Nopakun, J; Messer, H H et al. (1988) Retention of skeletal fluoride during bone turnover in rats. J Nutr 118:362-6
Menczel, J; Singer, L; Ophaug, R H (1987) An investigation of calcium intake, 1-alpha(OH)D3, and etidronate on bone. Bone 8:91-4
Kajander, K C; Uhland, R; Ophaug, R H et al. (1987) Topical fluoride in orthodontic bonding. Angle Orthod 57:70-6
Ophaug, R H; Jenkins, G N; Singer, L et al. (1987) Acid diffusion analysis of different forms of fluoride in human dental plaque. Arch Oral Biol 32:459-61
Ron, M; Singer, L; Menczel, J et al. (1986) Fluoride concentration in amniotic fluid and fetal cord and maternal plasma. Eur J Obstet Gynecol Reprod Biol 21:213-8
Okazaki, M; Ophaug, R H; Singer, L (1985) Promotion of bone dissolution by excessive fluoride in acidic buffer solution. Biomaterials 6:277-80
Singer, L; Ophaug, R H; Harland, B F (1985) Dietary fluoride intake of 15-19-year-old male adults residing in the United States. J Dent Res 64:1302-5
Ophaug, R H; Singer, L; Harland, B F (1985) Dietary fluoride intake of 6-month and 2-year-old children in four dietary regions of the United States. Am J Clin Nutr 42:701-7